Computational Study of Viral Segments Inserted within the Regions of Human Genome
P. Pandarinath*, M. Shashi and A. Appa Rao
Department of Computer Sciences, College of Engineering (A) Andhra University, Visakhapatnam- 530 003, Andhra Pradesh, India
- *Corresponding Author:
- Dr. P. Pandarinath
Department of Computer Sciences
College of Engineering (A) Andhra University
Andhra Pradesh, India
E-mail: [email protected]
Received Date: August 25, 2010; Accepted Date: August 28, 2010; Published Date: August 28, 2010
Citation: Pandarinath P, Shashi M, Rao AA (2010) Computational Study of Viral Segments Inserted within the Regions of Human Genome. J Comput Sci Syst Biol 3:074-075. doi: 10.4172/jcsb.1000060
Copyright: © 2010 Pandarinath P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Humans have been carrying unwanted viral gene segments since many years and reports suggests that approximately 3-8% of the human genome has been comprised of viral DNA. In this point of view, various viral sequences were downloaded from NCBI Tax Browser and scanned against complete genome of Homo sapiens for the presence of possible viral inserts in human genome. The results from the computational analysis revealed that dengue virus resulted in viral segments inserted in the intron regions of human genome and exon region insertions were observed with polio and simian enterovirus. The alignments which show > 25-30 residues, 90-100% identities and the sequences located in the exon regions were considered.