alexa Concentration of the CS-846 Epitope in Serum and Synovi
ISSN: 2327-5146

General Medicine: Open Access
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Research Article

Concentration of the CS-846 Epitope in Serum and Synovial Fluid of Horses with Different Grades of Osteochondral Fragments in the Carpal Joints

Hipolito Chavez1, Hugo Folch2, Oscar Araya3, Benjamin Uberti4 and Gabriel Moran4*

1Faculty of Veterinary Medicine, Universidad San Sebastian, Concepción, Chile

2Department of Immunology, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile

3Department of Clinical Veterinary Sciences, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia

4Department of Pharmacology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile

*Corresponding Author:
Gabriel Moran
Department of Pharmacology
Faculty of Veterinary Sciences
Universidad Austral de Chile
Valdivia, Chile
Tel: +56-63-221936
Fax: +56-63-221444
E-mail: [email protected]

Received date: March 09, 2016; Accepted date: May 18, 2016; Published date: May 24, 2016

Citation: Hipolito C, Hugo F, Oscar A, Benjamin U, Gabriel M (2016) Concentration of the CS-846 Epitope in Serum and Synovial Fluid of Horses with Different Grades of Osteochondral Fragments in the Carpal Joints. Gen Med (Los Angeles) 4:242. doi:10.4172/2327-5146.1000242

Copyright: © 2016 Hipolito C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of this study was to determine serum and synovial concentrations of the CS-846 epitope of articular cartilage aggrecan, in horses with a radiological diagnosis of osteochondral fragmentation (OF). For this purpose, 20 thoroughbred horses with unilateral radiocarpal or intercarpal OF were used, and 10 clinically and radiologically healthy Thoroughbred horses were assigned to the control group. Serum and synovial concentrations of the CS-846 epitope were measured in both groups by means of ELISA. The concentration of the CS-846 epitope in synovial fluid was significantly higher in carpal joints with moderate articular damage (grade 2 OF) than in the control group or in horses with severe disease (grade 3 and 4 OF). In serum, non-statistical differences in the concentration of the CS-846 epitope were observed between horses with OF and controls. We conclude that the concentration of CS-846 epitope in synovial fluid suggests an increase in cartilage aggrecan synthesis, which may be associated with the presence of moderate clinical disease. The CS-846 epitope concentration in synovial fluid may be a useful biomarker for the study of carpal OF in horses, providing a measure of the balance between cartilage synthesis and degradation in this equine disease.

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