alexa Concomitant Immune Thrombocytopenic Purpura and Crohn's Disease | OMICS International | Abstract
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

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Review Article

Concomitant Immune Thrombocytopenic Purpura and Crohn's Disease

Toru Shizuma*

Department of Physiology, School of Medicine, Tokai University, 143, Shimokasuya, Isehara, Kanagawa, 259-1193, Japan

*Corresponding Author:
Toru Shizuma
Department of Physiology, School of Medicine
Tokai University, 143, Shimokasuya
Isehara, Kanagawa, 259-1193, Japan
Tel: +81-0463-93-1121
Fax: +81-0463-93-6684
E-mail: [email protected]

Received date: Jun 15, 2015 Accepted date: Aug 05, 2015 Published date: Aug 10, 2015

Citation: Shizuma T (2015) Concomitant Immune Thrombocytopenic Purpura and Crohn’s Disease. J Blood Disord Transfus 6:295. doi: 10.4172/2155-9864.1000295

Copyright: © 2015 Shizuma T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The coexistence of immune (idiopathic) thrombocytopenic purpura (ITP) and Crohn’s disease (CD) is rare. We performed a review of cases of concomitant ITP and CD in the English and Japanese literature. Among 17 identified cases of concomitant ITP and CD, ITP was initially diagnosed in four cases and CD was initially diagnosed first in six cases. Simultaneous diagnoses were reported in the remaining seven cases. No fatalities were reported in any of the 17 cases. However, resistance or transient responses to standard therapies, such as glucocorticoids or intravenous immunoglobulin (IVIG), and splenectomy for the treatment of ITP were reported in a number of concomitant cases. Moreover, the administration of anti-tumor necrosis factor (TNF)-alpha antibodies was a commonly considered pharmacological therapy in cases of concomitant ITP and CD.

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