alexa Congenital and Acute Kidney Disease: Translational Rese
ISSN: 2327-5146

General Medicine: Open Access
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Review Article

Congenital and Acute Kidney Disease: Translational Research Insights from Zebrafish Chemical Genetics

Shahram Jevin Poureetezadi and Rebecca A Wingert*
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Corresponding Author : Rebecca A Wingert
Department of Biological Sciences
University of Notre Dame, 100 Galvin Life Sciences
Notre Dame, IN 46556, USA
Tel: (574)-631-0907
Fax: (574)-631-7413
E-mail: [email protected]
Received July 15, 2013; Accepted August 20, 2013; Published August 27, 2013
Citation: Poureetezadi SJ, Wingert RA (2013) Congenital and Acute Kidney Disease: Translational Research Insights from Zebrafish Chemical Genetics. Gen Med (Los Angel) 1:112. doi: 10.4172/2327-5146.1000112
Copyright: © 2013 Poureetezadi SJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Today, acute kidney injury (AKI) and congenital anomalies of the kidney and urinary tract (CAKUT) represent major issues in healthcare. Both AKI and CAKUT can lead to end stage renal disease (ESRD) that requires life-long medical care with renal replacement therapy. Renal replacement by dialysis is intensive, and kidney transplantation is restricted by organ availability. These limitations, along with the growing epidemic of patients affected by kidney disease, highlight the significant need to identify alternative ways to treat renal injury and birth defects. Drug discovery is one promising avenue of current research. Here, we discuss zebrafish chemical genetics and its latent potency as a method to rapidly identify small molecule therapeutics to accelerate recovery after AKI. Specifically, we review two groundbreaking studies that have recently provided a template to screen for compounds that expand the renal progenitor field in development that were capable of treating AKI in both the zebrafish and the mouse. These new findings demonstrate that drug discovery using zebrafish can be used for relevant translational research to identify clinical interventions for renal conditions in humans.


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