alexa Conjunctival Dysplasia and Atypical Secondary Acquired Melanosis in Xeroderma Pigmentosum
ISSN: 2157-7099

Journal of Cytology & Histology
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Case Report

Conjunctival Dysplasia and Atypical Secondary Acquired Melanosis in Xeroderma Pigmentosum

Lim EWL1, Lim L2, Jajeh IA3* and Jayasinghe LS2,4

1Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore

2Corneal and External Eye Disease Service, Singapore National Eye Centre, Singapore

3Histopathology, Pathology Department, Singapore General Hospital, Singapore

4Department of Ophthalmology, Teaching Hospital Kandy, Sri Lanka

*Corresponding Author:
Issam Al
Jajeh Pathology, Mailing address: 20 College Road
Academia, Level 10, 169856, Singapore
Tel: 6-5 6321 4875
Fax: +65 6222 6826
E-mail: [email protected]

Received Date: February 15, 2016; Accepted Date: April 15, 2016; Published Date: April 25, 2016

Citation: Lim EWL, Lim L, Jajeh IA , Jayasinghe LS (2016) Conjunctival Dysplasia and Atypical Secondary Acquired Melanosis in Xeroderma Pigmentosum. J Cytol Histol 7: 1000405. doi:10.4172/2157-7099.1000405

Copyright: © 2016 Lim EWL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Xeroderma pigmentosum (XP) is a rare genetic disease associated with hypersensitivity to ultraviolet radiation resulting in cutaneous, ocular and neurological abnormalities. Ocular involvement typically includes photophobia, keratitis, corneal opacity and atrophy of the eyelids, along with carcinomas and melanomas. We report a rare case of conjunctival dysplasia and atypical secondary acquired melanosis in a patient with XP. A 9 year old Indian boy with a history of XP presented with conjunctival lesions over the course of one year. The ocular involvement manifested as conjunctival actinic keratosis/epithelial dysplasia and atypical secondary acquired melanosis. To the best of our knowledge, atypical secondary acquired melanosis has not previously been reported in association with XP in the literature. We present our clinical and histopathological findings of conjunctival dysplasia and atypical secondary acquired melanosis in this patient. Although acquired melanosis with atypia is known to occur and is often reported as a cutaneous manifestation of XP, it is rarely reported as a conjunctival manifestation in XP. It is possible that the early acquired melanosis is overshadowed by more visible conjunctival intraepithelial neoplasia (CIN) lesions.

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