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ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Research Article

Conservation of Binding Epitopes for Monoclonal Antibodies on the Rabies Virus Glycoprotein

Natalia A Kuzmina1*, Ivan V Kuzmin1,2, James A Ellison1 and Charles E Rupprecht1,3

1Centers for Disease Control and Prevention, Atlanta, USA

2Aravan, LLC, Lilburn, USA

3Global Alliance for Rabies Control, Kansas, USA

*Corresponding Author:
Natalia A Kuzmina
Centers for Disease Control and Prevention
1600 Clifton Rd., bldg. 17, MS G-33, Atlanta, GA, USA
Tel: 404-639-1050
Fax: 404-639-1564
E-mail: [email protected]

Received Date: March 13, 2013; Accepted Date: March 28, 2013; Published Date: March 30, 2013

Citation: Kuzmina NA, Kuzmin IV, Ellison JA, Rupprecht CE (2013) Conservation of Binding Epitopes for Monoclonal Antibodies on the Rabies Virus Glycoprotein. J Antivir Antiretrovir 5:037-043. doi: 10.4172/jaa.1000061

Copyright: © 2013 Kuzmina NA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The global need for rabies immune globulin (RIG) for post-exposure prophylaxis (PEP) is significant. The cost of RIG, either of equine or human origin, is prohibitive for most patients in developing countries. Limitations of supply may occur worldwide. Several virus-neutralizing monoclonal antibodies (MAbs), binding to the rabies virus glycoprotein have been proposed as a replacement of conventional RIG in human PEP due to the ability of largescale production at a reduced cost. In the present study we analyzed 1,042 rabies virus glycoprotein sequences, generated de novo and retrieved from GenBank, to determine the conservation of binding epitopes for several well characterized rabies virus-neutralizing MAbs. Our analysis demonstrated that the use of a single MAb for rabies PEP is inappropriate, because certain viral sequences had critical amino acid substitutions in binding epitopes for each MAb. Rather, a cocktail of MAbs, targeting non-overlapping epitopes, offers a reliable alternative, as no sequences from our study harbored critical substitutions in binding sites for two or more MAbs simultaneously.

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