Conserved HIV Wide Spectrum Antipeptides-A Hope for HIV Treatment
Antipeptide or inhibiting peptide aims to prevent virus/coreceptor interaction. HIV inhibting peptide dataset collected from HIPdb database was used in this study. There are 110 HIV inhibiting peptide is present in HIPdb database. Multiple Sequence Alignment (MSA) of all total 110 antipeptide has been performed and got some best conserved antipeptides. Next, prediction of antigenicity method was used for finding the maximum antigenicity out of the 14 conserved inhibiting peptides. All peptides were screened for hydrophobicity as low hydrophobicity induces humoral mediated immunity. Afterwards, Antimicrobial Peptide Prediction (AMP) and its classification was performed. In this study, PWQGGRRKFR and KYRRFRWKFK are the promising HIV antipeptide for AIDS treatment. This study will help scientists to promote research for better understanding of HIV treatment in forms of drug and vaccine development.