alexa Continuous Force Measurement in Limb Lengthening | OMICS International | Abstract
ISSN: 2155-9538

Journal of Bioengineering & Biomedical Science
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Research Article

Continuous Force Measurement in Limb Lengthening

Tariq Rahman1,*, Robert E. Akins1, Jinyong Wee2 and William G. Mackenzie1

1Nemours/Alfred I. duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA

2School of Biomedical Engineering, Drexel University, Philadelphia, PA 19104, USA

*Corresponding Author:
Tariq Rahman, PhD
Nemours Biomedical Research
Nemours/Alfred I. duPont Hospital for Children
P.O. Box 269, Wilmington, DE 19899, USA
Tel: 302-651-6831
Fax: 302-651-6782
E-mail: [email protected]

Received Date: November 21, 2011; Accepted Date: December 07, 2011; Published Date: December 08, 2011

Citation: Rahman T, Akins RE, Wee J, Mackenzie WG (2011) Continuous Force Measurement in Limb Lengthening. J Bioeng Biomed Sci 1:104. doi:10.4172/2155-9538.1000104

Copyright: © 2011 Rahman T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Complications of limb lengthening include stress on soft tissue, premature consolidation, and bone non-union. This study reports on the development and testing of instrumentation that continually measures distraction forces in rabbits with the aim of relating the forces developed to bone growth and muscle physiology. A full bridge strain gage resistor set mounted to a unilateral distractor measured distraction force and stored the data on a self-contained logger attached to a jacket worn by the rabbit. Two rabbits underwent limb lengthening on one hind leg. Lengthening was set at 0.5 mm/ day, twice per day for a total of 12 mm. Tibialis anterior muscle and proximal and distal tibial growth plates from the operated and control legs were harvested after euthanasia for histomorphometric analysis. Radiographs were taken periodically throughout lengthening. Force data show characteristic overall increase in force. Force steadily decays after each lengthening. Peak forces appear to correlate with time between lengthenings. Histologic data show that the operated leg had an increased preponderance of type I muscle fibers, a decrease in type-I and type-II muscle fiber diameters, and a decrease in endogenous bone growth at the distal growth plate. Histomorphometric analysis showed that the lengthening paradigm employed altered distal bone growth and muscle fiber physiology during lengthening.

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