alexa Contribution of Next-generation Sequencing in a Case of Metastatic Breast Carcinoma with Pulmonary Lesions | OMICS International | Abstract

Journal of Lung Cancer Diagnosis & Treatment
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Contribution of Next-generation Sequencing in a Case of Metastatic Breast Carcinoma with Pulmonary Lesions

Kotecki N1, Escande F2, Surmei-Pintilie E3, Abramovici O4, Bonneterre J1 and Dansin E5*

1Department of Senology, PBC Oscar Lambret, Lille, France

2CHU - Regional Platform of Molecular Genetics COL Cancers, University Hospital, Lille, France

3Department of Thoracic Surgery, University Hospital Calmette Hospital, Lille, France

4Unit of of Morphology and Molecular Pathology Unit, PBC Oscar Lambret, Lille, France

5Department of General Oncology, Oscar PBC Lambret, Lille, France

*Corresponding Author:
Dr. Eric Dansin
Department of General Oncology
Oscar PBC Lmbret three Kbmle 59020 Lille, France
Tel: +33 320295920
Fax: +33 320295963
E-mail: [email protected]

Received date: Mar 18, 2016; Accepted date: Apr 27, 2016; Published date: May 06, 2016

Citation: Kotecki N, Escande F, Surmei-Pintilie E, Abramovici O, Bonneterre J, et al. (2016) Contribution of Next-generation Sequencing in a Case of Metastatic Breast Carcinoma with Pulmonary Lesions. J Lung Cancer Diagn Treat 1:103. doi:10.4172/jlcdt.1000103

Copyright: © 2016 Kotecki N et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Next-Generation Sequencing (NGS) provide specific cancer-related gene-sequence information which can be helpful for diagnosis and clinical decision. Here we describe the case of a patient diagnosed with HER2 positive metastatic breast cancer and successive pulmonary lesions. Despite large immunohistochemical assays. It was not possible to distinguish on first thoracic specimen between primary lung adenocarcinoma and metastasis from breast carcinoma. NGS analysis on second thoracic sample detected somatic mutations in PiK3CA and TP53 genes. This mutation profile was identical to the previously resected adenocarcinoma. NGS contribute to diagnose metachronous primary lung carcinoma and to propose a thoracic treatment in addition to systemic management of metastatic breast carcinoma. Our case report emphasizes the usefulness of NGS to guide diagnosis and treatment in the objective of precision medicine.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version