alexa Contribution of Next-generation Sequencing in a Case of Metastatic Breast Carcinoma with Pulmonary Lesions

Journal of Lung Cancer Diagnosis & Treatment
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Review Article

Contribution of Next-generation Sequencing in a Case of Metastatic Breast Carcinoma with Pulmonary Lesions

Kotecki N1, Escande F2, Surmei-Pintilie E3, Abramovici O4, Bonneterre J1 and Dansin E5*

1Department of Senology, PBC Oscar Lambret, Lille, France

2CHU - Regional Platform of Molecular Genetics COL Cancers, University Hospital, Lille, France

3Department of Thoracic Surgery, University Hospital Calmette Hospital, Lille, France

4Unit of of Morphology and Molecular Pathology Unit, PBC Oscar Lambret, Lille, France

5Department of General Oncology, Oscar PBC Lambret, Lille, France

*Corresponding Author:
Dr. Eric Dansin
Department of General Oncology
Oscar PBC Lmbret three Kbmle 59020 Lille, France
Tel: +33 320295920
Fax: +33 320295963
E-mail: [email protected]

Received date: Mar 18, 2016; Accepted date: Apr 27, 2016; Published date: May 06, 2016

Citation: Kotecki N, Escande F, Surmei-Pintilie E, Abramovici O, Bonneterre J, et al. (2016) Contribution of Next-generation Sequencing in a Case of Metastatic Breast Carcinoma with Pulmonary Lesions. J Lung Cancer Diagn Treat 1:103. doi:10.4172/jlcdt.1000103

Copyright: © 2016 Kotecki N et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Next-Generation Sequencing (NGS) provide specific cancer-related gene-sequence information which can be helpful for diagnosis and clinical decision. Here we describe the case of a patient diagnosed with HER2 positive metastatic breast cancer and successive pulmonary lesions. Despite large immunohistochemical assays. It was not possible to distinguish on first thoracic specimen between primary lung adenocarcinoma and metastasis from breast carcinoma. NGS analysis on second thoracic sample detected somatic mutations in PiK3CA and TP53 genes. This mutation profile was identical to the previously resected adenocarcinoma. NGS contribute to diagnose metachronous primary lung carcinoma and to propose a thoracic treatment in addition to systemic management of metastatic breast carcinoma. Our case report emphasizes the usefulness of NGS to guide diagnosis and treatment in the objective of precision medicine.


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