alexa Control of Simultaneous Osteogenic and Adipogenic Differentiation of Mesenchymal Stem Cells | OMICS International | Abstract
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
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Research Article

Control of Simultaneous Osteogenic and Adipogenic Differentiation of Mesenchymal Stem Cells

Rong Cai1,2, Tomoko Nakamoto1, Takashi Hoshiba3, Naoki Kawazoe1 and Guoping Chen1,2*

1Tissue Regeneration Materials Unit, International Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305- 0044, Japan

2 Department of Materials Science and Engineering, Graduate School of Pure and Applied Sciences, Tsukuba University, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan

3Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan

*Corresponding Author:
Guoping Chen
Principal Investigator and Unit
Director, Tissue Regeneration Materials Unit
International Center for Materials Nanoarchitectonics
National Institute for Materials Science
1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
Tel: +81-29-860-4496
Fax: +81-29-860-4714
E-mail: [email protected]

Received date: July 14, 2014; Accepted date: August 01, 2014; Published date: August 03, 2014

Citation: Cai R, Nakamoto T, Hoshiba T, Kawazoe N, Chen G (2014) Control of Simultaneous Osteogenic and Adipogenic Differentiation of Mesenchymal Stem Cells. J Stem Cell Res Ther 4:223. doi: 10.4172/2157-7633.1000223

Copyright: © 2014 Cai R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Mesenchymal stem cells (MSCs) are pluripotent cells which can differentiate into several distinct lineages such as osteoblasts and adipocytes. Osteogenesis and adipogenesis of MSCs induced with specific induction factors have been well exploited. However, it is not clear how simultaneous osteogenesis and adipogenesis of MSCs is balanced by the composition of induction medium. In this study, MSCs were cultured in the mixture medium at different ratio of osteogenic medium (OM) and adipogenic medium (AM) to investigate the simultaneous osteogenesis and adipogenesis of MSCs. Differentiation was investigated by histological staining and real-time PCR analysis. The results showed that adipogenesis was dosage dependent on the concentration of adipogenic induction factors, while osteogenesis was not. The balance of osteogenesis and adipogenesis could be control by different ratio of osteogenic and adipogenic media. The results will be useful for controlling stem cell differentiation.


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