alexa Controlled Ovarian Hyperstimulation through Gonadotrophin releasing Hormone Agonist for Patients at Risk of Hyperstimulation Syndrome
ISSN: 2375-4508

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology
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Research Article

Controlled Ovarian Hyperstimulation through Gonadotrophin releasing Hormone Agonist for Patients at Risk of Hyperstimulation Syndrome

Antonio Maselli1, Martin Wilding1*, Sylvia del Grande1, Stefania Riccio1, Loredana Di Matteo1,2 and Brian Dale1
1Centro Fecondazione Assistita, Clinica Villa del Sole, Via Manzoni 15, 80122 Napoli, Italy
2Facolta di Medicina e Chirurgia, II Università degli Studi di Napoli, Via Costantinopoli, 16, 80100 Napoli, Italy
*Corresponding Author : Dr. Martin Wilding
Centro Fecondazione Assistita
Clinica Villa del Sole
Via Manzoni 15, 80122 Napoli, Italy
Tel: 081641689
Fax: 0815479251
E-mail: [email protected]
Received December 12, 2011; Accepted February 10, 2012; Published February 20, 2012
Citation: Maselli A, Wilding M, Grande SD, Riccio S, Matteo LD, et al. (2012) Controlled Ovarian Hyperstimulation through Gonadotrophin releasing Hormone Agonist for Patients at Risk of Hyperstimulation Syndrome. J Fertiliz in vitro 2:103. doi:10.4172/2165-7491.1000103
Copyright: © 2012 Maselli A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background:Patients at high risk of OHSS can experience difficulty in completing an IVF cycle with the administration of gonadotrophins. Here, we test a unique low-dose GnRH agonist protocol.

Methods: 0.1mg triptorlin acetate (decapeptyl) was administered to 18 patients at high risk of OHSS from day 5 of the menstrual cycle. Oocyte retrieval was performed 36 hours after the administration of 10000 IU human chorionic gonadotrophin, when follicles of 18-20mm were observed. Oocytes were fertilised in vitro and embryos transferred on day 3.

Results: Patients produced a mean of 4.1 ± 0.96 oocytes. After ICSI, a mean of 3.0 ± 0.84 embryos were transferred to the uterus. A total of 5 pregnancies were obtained from the 18 cycles. No patients were affected by OHSS.

Conclusions: Low-dose injections of GnRH analogues can cause multiple follicular development, mature oocytes and pregnancies in patients at risk of OHSS. This novel COH protocol appears safe and applicable as a valuable alternative to the natural cycle.

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