alexa Conversion to Steroid-Responsiveness in a Patient with
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
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Case Report

Conversion to Steroid-Responsiveness in a Patient with Motor-Dominant Chronic Inflammatory Demyelinating Polyneuropathy

Kataoka H*, Kobayashi Y, Terashima M, Sugie K and Ueno S

Department of Neurology, Nara Medical University, Kashihara, Nara, Japan

*Corresponding Author:
Hiroshi Kataoka
Department of Neurology, Nara Medical University
840 Shijo-cho, Kashihara, Nara 634-8522, Japan
Tel: +81-744-29-8860
Fax: +81-744-24-6065
E-mail: [email protected]

Received date: July 25, 2013; Accepted date:August 06, 2013; Published date: August 08, 2013

Citation: Kataoka H, Kobayashi Y, Terashima M, Sugie K, Ueno S (2013) Conversion to Steroid-Responsiveness in a Patient with Motor-Dominant Chronic Inflammatory Demyelinating Polyneuropathy. J Genet Syndr Gene Ther 4:166. doi:10.4172/2157-7412.1000166

Copyright: © 2013 Kataoka H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The subtypes of chronic inflammatory demyelinating polyneuropathy (CIDP) differ in clinical presentation,
electrophysiological and laboratory features, and response to treatment. Steroid therapy is now accepted as a firstor
second-line treatment for CIDP. Patients with steroid-resistant CIDP have been reported, especially among those
with pure-motor or motor-dominant CIDP. The clinical and prognostic features of patients with motor dominant CIDP
are poorly understood. We describe a patient with steroid-unresponsive motor dominant CIDP who subsequently
responded to steroid therapy and review previously reported patients with motor dominant CIDP. Most patients
with motor-dominant CIDP did not respond to steroids, but remarkably improved after treatment with intravenous
immunoglobulins. Our findings suggest that some patients with steroid-unresponsive motor-dominant CIDP can
subsequently become responsive to steroid therapy.


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