Cooperative Interaction between the Alpha1-Adrenoceptors (ÃÂ±1-AR) and Transient Receptor Potential (TRP) Triggers a Proliferative Cell Signal in Prostate Cancer Cell LinesGiorgio Santoni1*, Maria Beatrice Morelli1,2, Consuelo Amantini3, Matteo Santoni4, Massimo Nabissi1, Claudio Cardinali1,4, Fabio Del Bello5, Alessandro Piergentili5and Wilma Quaglia5
- *Corresponding Author:
- Giorgio Santoni
PhD, School of Pharmacy, Experimental Medicine Section
University of Camerino, Via Madonna delle Carceri
Tel: +39 0737403312
Fax: +39 0737630618
E-mail: [email protected]
Received date: September 03, 2015; Accepted date: November 04, 2015; Published date: November 11, 2015
Citation: Santoni G, Morelli MB, Amantini C, Santoni M, Nabissi M, et al. (2015) Cooperative Interaction between the Alpha1-Adrenoceptors (α1-AR) and Transient Receptor Potential (TRP) Triggers a Proliferative Cell Signal in Prostate Cancer Cell Lines. J Genet Syndr Gene Ther 6:275. doi:10.4172/2157-7412.1000275
Copyright: © 2015 Santoni G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Calcium (Ca2+) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are unknown. Santoni and Quaglia groups investigated the correlation between alpha1D-adrenergic receptor (α1D-AR) and the transient receptor potential vanilloid type 1 (TRPV1) ion channel expression in PCa cells. The α1D-AR and TRPV1 mRNAs are increased in PCa compared to BPH. α1D-AR and TRPV1 are co-expressed in PCa cells. Norepinephrine (NE) induced α1D-AR- and TRPV1-dependent protons release, Ca2+ flux in PC3 cells and activation of PLC, PKC and ERK path-ways that stimulated PC3 cell proliferation. Similarly, a role for TRPC6 or GPR55 in α1-AR-dependent proliferation of mesangial cells and PCa cells was reported. Overall, a crosstalk between α1-AR and TRPs in PCa cells, involved in the control of cell proliferation has been demonstrated. These data strongly promote a putative novel pharmacological approach in the treatment of PCa by targeting both α1-AR and TRP channels.