Copper Oxidation State and Mycobacterial Infection
Laboratory of Biochemistry and Molecular Biology, Tomsk State University, Prospect Lenina, Tomsk, Russia
- *Corresponding Author:
- Solioz M
Laboratory of Biochemistry and Molecular Biology
Tomsk State University
Prospect Lenina 36
634050 Tomsk, Russia
Tel: 923 403 5002
E-mail: [email protected]
Received date: March 28, 2016; Accepted date: May 20, 2016; Published date: May 27, 2016
Citation: Solioz M (2016) Copper Oxidation State and Mycobacterial Infection. Mycobact Dis 6:210. doi:10.4172/2161-1068.1000210
Copyright: © 2016 Solioz M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copper in aerobic environments prevails as cupric ions, Cu2+, but inside cells, is usually present as cuprous ions, Cu+. Cu+ is considerably more toxic to bacteria than Cu2+. Phagosomes employ, among other mechanisms, Cu+ to create a hostile environment for engulfed bacteria. Bacteria can reduce or oxidize copper by various mechanisms. How such reactions could affect bacterial survival in phagosomes is discussed, with a focus onMycobacteria.