alexa Cordycepin from Hot Water Extract of Cordyceps militaris Induce Apoptosis in Human Non-Small Lung Carcinoma upon Activation of A3 Adenosine Receptors

Journal of Traditional Medicine & Clinical Naturopathy
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Research Article

Cordycepin from Hot Water Extract of Cordyceps militaris Induce Apoptosis in Human Non-Small Lung Carcinoma upon Activation of A3 Adenosine Receptors

Felix Shih-Hsiang Hsiao1, Yu-Hsiang Yu2, Pramod Shah3, Witold Stanisław Proskura4, Andrzej Dybus4, Ching-Han Huang2, Yi-Lin Chen2 and Yeong-Hsiang Cheng2*

1Department of Animal Science and Biotechnology, Tunghai University, Taichung 40704, Taiwan

2Department of Biotechnology and Animal Science, National I-Lan University, Yilan City, Yilan County, Taiwan

3Department of Biomedical Science and Engineering, National Central University, Taoyuan City 32001, Taiwan

4Laboratory of Molecular Cytogenetics, West Pomeranian University of Technology, 71-466 Szczecin, Poland

*Corresponding Author:
Cheng YH
Department of Biotechnology and Animal Science
National Ilan University
No. 1, Sec. 1, Shennong Road
Yilan City, Yilan County 260, Taiwan
Tel: +886-3-931-7712
Fax: +886-3-935-4794
E-mail: [email protected]

Received Date: July 17, 2017; Accepted Date: August 07, 2017; Published Date: August 14, 2017

Citation: Hsiao FSH, Yu YH, Shah P, Proskura WS, Dybus A, et al. (2017) Cordycepin from Hot Water Extract of Cordyceps militaris Induce Apoptosis in Human Non-Small Lung Carcinoma upon Activation of A3 Adenosine Receptors. J Tradit Med Clin Natur 6:234.

Copyright: © 2017 Hsiao FSH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Cordyceps militaris hot water extract (CMHW) containing cordycepin (cordycepin-CMHW) was used to study the anti-cancer effects in human A549 non-small cell lung carcinoma cells. Our results showed cordycepin-CMHW can inhibit cell proliferations in A549 cells by activating A3 adenosine receptor (A3AR) via the inactivation of Akt pathways. Cordycepin-CMHW can also induce apoptosis in the A549 cells by enhancing DNA fragmentation and chromatin condensation. We further observed that cordycepin-CMHW up-regulated caspase-9 and increased cleavage of caspase-3 and poly ADP ribose polymerase (PARP) in A549 cells. The results suggested cordycepin-CMHW is a highly selective treatment to de-regulation of the cell proliferation and apoptosis in non-small cell lung carcinoma via signaling pathways generated by A3AR activation.


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