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Corneal Gene Therapy in Veterinary Medicine: A Review | OMICS International | Abstract
ISSN: 2157-7579

Journal of Veterinary Science & Technology
Open Access

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Review Article

Corneal Gene Therapy in Veterinary Medicine: A Review

Ann P. Bosiack1,2, Elizabeth A. Giuliano2 and Rajiv R. Mohan1,2,3*

1Harry S. Truman Veterans Memorial Hospital, Columbia, Missouri, USA

2College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA

3Mason Eye Institute, School of Medicine, University of Missouri, Columbia, Missouri, USA

*Corresponding Author:
Rajiv R. Mohan, Ph.D
Mason Eye Institute, EC-210, School of Medicine
University of Missouri, 1 Hospital Dr Columbia, MO 65212
Tel: (573) 884-1449
Fax: (573) 814-6551
E-mail: [email protected]

Received date: Dececmber 14, 2011; Accepted date: January 28, 2018; Published date: February 04, 2012

Citation: Bosiack AP, Giuliano EA, Mohan RR (2012) Corneal Gene Therapy in Veterinary Medicine: A Review. J Veterinar Sci Technol S8:001. doi:10.4172/2157-7579.S8-001

Copyright: © 2012 Bosiack AP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The cornea is an ideal target for gene therapy due to its accessibility, immune-privileged nature, and ability to perform frequent non-invasive assessment. Gene therapy has been studied in animal models of ocular corneal graft rejection, neovascularization, wound healing, fibrosis, macular degeneration, optic neuropathy, and retinal degeneration. Medical research has widely used animal models in the pursuit of improved therapeutic strategies intended to aid people. In this review we summarize the vectors currently used in ocular gene therapy and the potential applications of emerging new strategies for use in veterinary medicine.

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