Reach Us +44-1647-403003
Coronary Artery Spasm, Hypertension, Hypokalemia and Licorice | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Coronary Artery Spasm, Hypertension, Hypokalemia and Licorice

Ewa Konik1*, Emily Graham Kurtz1, Flora Sam2 and Douglas Sawyer1
1Vanderbilt University, Nashville, TN, USA
2Boston University School of Medicine, Boston, MA, USA
Corresponding Author : Ewa Konik, MD
Vanderbilt University
Nashville, TN, USA
E-mail: [email protected]
Received March 05, 2012; Accepted May 05, 2012; Published May 14, 2012
Citation: Konik E, Kurtz EG, Sam F, Sawyer D (2012) Coronary Artery Spasm, Hypertension, Hypokalemia and Licorice. J Clin Case Rep 2:143. doi:10.4172/2165-7920.1000143
Copyright: © 2012 Konik E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Hypertension with hypokalemia, especially in a patient off diuretics, suggests a secondary hypertension due to an increase in mineralocorticoid activity, for example, primary increases in renin, aldosterone, or nonaldosterone mineralocorticoid secretion or an increased mineralocorticoid-like effect.
Mineralocorticoid Receptors (MR) preferentially bind cortisol. A mineralocorticoid effect of cortisol is avoided in some tissues by expression of 11-Beta Hydroxysteroid Dehydrogenase type 2 (11 BHSD2), the enzyme responsible for transformation of cortisol to its 11-keto derivative (cortisone), which has minimal affinity for MR receptors. Only when cortisol is converted to the inactive cortisone can aldosterone bind to the MR. Rare congenital deficiency of 11 BHSD2 or its inhibition by licorice consumption mimics hyperaldosteronic state.

Recommended Conferences

14th Global Pharmacovigilance And Clinical Trials Summit

Sydney, Australia

38th International Conference on Dental & Oral Care

Yokohama, Japan

World Conference on Clinical and Medical Case Reports

Perth, Australia
Share This Page