Correlation between CMV Infection and NODAT
- Corresponding Author:
- Dr. Matej StanÄík
Clinic of Internal Medicine I
University Hospital Martin and Jessenius Faculty of Medicine
Comenius University, Slovak Republic
Tel: +421 43 4203 485
E-mail: [email protected]
Received date: May 25, 2016; Accepted date: June 13, 2016; Published date: June 20, 2016
Citation: Dedinská I, Laca Ä½, Miklušica J, Kantárová D, Ulinako J, et al. (2016) Correlation between CMV Infection and NODAT. J Metabolic Synd 5:205. doi:10.4172/2167-0943.1000205
Copyright: © 2016 Dedinská I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: New-onset diabetes mellitus after transplantation (NODAT) is a well-known complication of transplantation.
Materials and methods: Retrospectively, we detected CMV replication (PCR) in every month after transplantation of kidney in the first 12 months after transplantation in patients in a homogenous group from the aspect of immunosuppresion.
Results: In the group of 167 patients (control group: n = 103, NODAT group: n = 64), the average value of CMV viremia was without any significant difference between the NODAT group and the control group (P = 0.9285). In the 10th month after kidney transplantation, we recorded significantly higher CMV viremia in the NODAT group (p < 0.0001), however, in the multi variant analysis, that difference was not confirmed. Thus, in our group, CMV is of no relevance with the development of NODAT in the monitored period. The survival of patients and graft was 12 months after kidney transplantation without any statistically significant difference between the monitored groups (P = 0.6113 - survival of the patient; P = 0.5381 – survival of the graft).
Conclusion: Our analysis shows that in regular monitoring of CMV viremia and applying chemoprophylaxison the risk recipeints, CMV is not the risk factor for NODAT.