Correlation between Mitral (E/A), Pulmonary (At/Et) Ratios in Doppler Mode and the Biological Marker of Fetal Lung Maturity (Lecithin/Sphingomyelin Ratio)Caloone J1,2*, Cortet M3, Boisson-Gaudin C4, Chicaud B1, Chambon V4, Rudigoz RC1 and Huissoud C1,5
3Hospices Civils de Lyon, Service de Biostatistique, F-69003, Lyon, France, Université de Lyon, F-69000, Lyon, France; Université Lyon 1, F-69100, Villeurbanne, France; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie évolutive, équipe Biostatistique-Santé, F-69100, Villeurbanne, France
- *Corresponding Author:
- Caloone J
Laboratory of Therapeutic Applications of Ultrasound
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Received date: February 22, 2014; Accepted date: April 24, 2014; Published date: April 30, 2014
Citation: Caloone J, Cortet M, Boisson-Gaudin C, Chicaud B, Chambon V, et al. (2014) Correlation between Mitral (E/A), Pulmonary (At/Et) Ratios in Doppler Mode and the Biological Marker of Fetal Lung Maturity (Lecithin/Sphingomyelin Ratio). Gynecol Obstet (Sunnyvale) 4:219. doi: 10.4172/2161-0932.1000219
Copyright: © 2014 Caloone J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To analyse the correlation between Doppler fetal heart indicators such as mitral ratio (E/A), acceleration time/ejection time (AT/ET) ratio in the main of pulmonary artery to the lecithin/sphingomyelin ratio (L/S) dosed in the amniotic fluid.
Material and Methods: Prospective study including singletons between 24 and 39 weeks of gestation, for whom caesarean delivery was planned. E/A and AT/ET ratios were realised during the 24 hours before birth. The L/S ratio was assayed by thin-layer chromatography, from samples of amniotic fluid.
Results: Thirty fetus were included, for a median (IQR) gestational age of 37 weeks (33.8-38.7) and a median weight birth of 2600 g (1888-3140). The correlation between the E/A and L/S ratios was positive: r = 0.56 (95% CI [0.24–0.76], p<0.01) while the correlation between AT/ET and L/S ratios was negative: r = - 0.44 (95% CI [(-0.69) – (-0.10)], p<0.01). The median E/A ratio in the hyaline membrane disease group was lower than in the group without (0.55 vs. 0.78, p< 0.01), while the median AT/ET ratio was higher (0.31 vs. 0.21, p= 0.011).