alexa Correlation between Mitral (E/A), Pulmonary (At/Et) Ratios in Doppler Mode and the Biological Marker of Fetal Lung Maturity (Lecithin/Sphingomyelin Ratio) | Abstract
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

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Research Article

Correlation between Mitral (E/A), Pulmonary (At/Et) Ratios in Doppler Mode and the Biological Marker of Fetal Lung Maturity (Lecithin/Sphingomyelin Ratio)

Caloone J1,2*, Cortet M3, Boisson-Gaudin C4, Chicaud B1, Chambon V4, Rudigoz RC1 and Huissoud C1,5

1Hospices Civils de Lyon, Service de Gynécologie et Obstétrique, Hôpital Universitaire de la Croix Rousse, Lyon F-69004, France

2Inserm, U1032, LabTau, Lyon, F-69003, France ; Université de Lyon, Lyon, F-69003, France

3Hospices Civils de Lyon, Service de Biostatistique, F-69003, Lyon, France, Université de Lyon, F-69000, Lyon, France; Université Lyon 1, F-69100, Villeurbanne, France; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie évolutive, équipe Biostatistique-Santé, F-69100, Villeurbanne, France

4Hospices Civils de Lyon, Service de Biochimie, Hôpital Universitaire de la Croix Rousse, Lyon F-69004, France

5Stem Cell and Brain Research Institute, Institut National de la Sante et de la Recherche Médicale U846, 18 avenue du Doyen Lepine, Bron, France

*Corresponding Author:
Caloone J
Laboratory of Therapeutic Applications of Ultrasound
151 cours Albert Thomas, 69424 Lyon cedex 03, France
Tel: + 33 4 72 68 19 30
Fax: + 33 4 72 68 19 31
E-mail: [email protected]

Received date: February 22, 2014; Accepted date: April 24, 2014; Published date: April 30, 2014

Citation: Caloone J, Cortet M, Boisson-Gaudin C, Chicaud B, Chambon V, et al. (2014) Correlation between Mitral (E/A), Pulmonary (At/Et) Ratios in Doppler Mode and the Biological Marker of Fetal Lung Maturity (Lecithin/Sphingomyelin Ratio). Gynecol Obstet (Sunnyvale) 4:219. doi: 10.4172/2161-0932.1000219

Copyright: © 2014 Caloone J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: To analyse the correlation between Doppler fetal heart indicators such as mitral ratio (E/A), acceleration time/ejection time (AT/ET) ratio in the main of pulmonary artery to the lecithin/sphingomyelin ratio (L/S) dosed in the amniotic fluid.

Material and Methods: Prospective study including singletons between 24 and 39 weeks of gestation, for whom caesarean delivery was planned. E/A and AT/ET ratios were realised during the 24 hours before birth. The L/S ratio was assayed by thin-layer chromatography, from samples of amniotic fluid.

Results: Thirty fetus were included, for a median (IQR) gestational age of 37 weeks (33.8-38.7) and a median weight birth of 2600 g (1888-3140). The correlation between the E/A and L/S ratios was positive: r = 0.56 (95% CI [0.24–0.76], p<0.01) while the correlation between AT/ET and L/S ratios was negative: r = - 0.44 (95% CI [(-0.69) – (-0.10)], p<0.01). The median E/A ratio in the hyaline membrane disease group was lower than in the group without (0.55 vs. 0.78, p< 0.01), while the median AT/ET ratio was higher (0.31 vs. 0.21, p= 0.011).

Conclusion: The E/A, AT/ET, and L/S ratios are correlated. Further studies are necessary to confirm the interest of these Doppler heart indicators to assess the fetal lung maturity.


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