alexa Correlation between Ulcerative Colitis Endoscopic Index of Severity, Lichtiger Index and Fecal Calprotectin in Ulcerative Colitis Patients
ISSN: 2165-8048

Internal Medicine: Open Access
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Research Article

Correlation between Ulcerative Colitis Endoscopic Index of Severity, Lichtiger Index and Fecal Calprotectin in Ulcerative Colitis Patients

Nakov RV1*, Nakov VN1, Gerova VA1, Penchev PI1, Tankova L1 and Kundurzhiev TG2

1Clinical Center of Gastroenterology, University Hospital Queen Joanna, Medical University of Sofia 1527, Bulgaria

2Department of Social Medicine and Health Management, Section of Biostatistics, Medical University of Sofia, Bulgaria

Corresponding Author:
Radislav Nakov
Clinic of Gastroenterology “Tsaritsa Yoanna” University Hospital
1000 Sofia, Bulgaria
Tel: 359889807559
E-mail: [email protected]

Received Date: June 17, 2017; Accepted Date: July 25, 2017; Published Date: July 28, 2017

Citation: Nakov RV, Nakov VN, Gerova VA, Penchev PI, Tankova L, et al. (2017) Correlation between Ulcerative Colitis Endoscopic Index of Severity, Lichtiger Index and Fecal Calprotectin in Ulcerative Colitis Patients. Intern Med 7:248. doi: 10.4172/2165-8048.1000248

Copyright: © 2017 Nakov RV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Aim: The aim of the current study was to assess the correlation between the Ulcerative Colitis Endoscopic Index of Severity (UCEIS), Lichtiger Index and the fecal calprotectin (FC) levels in ulcerative colitis (UC) patients.

Methods: This prospective study included 58 patients with UC, referred for colonoscopy to our Center. The diagnosis of UC was based on the clinical, endoscopic, and histological criteria. FC was analyzed in stool samples by means of point-of-care desk-top Quantum Blue Reader® method.

Results: The UCEIS significantly correlated with levels of FC (r=0.869, p<0.001) and the Lichtiger Clinical Activity Index (r=0.862, p<0.001). Moreover, the Lichtiger Index demonstrated significant correlation with FC levels (r=0.869, p<0.001).

Conclusion: The strong correlation between clinical and endoscopic disease activity shows that FC is a useful biomarker for noninvasive activity monitoring in UC patients.


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