Correlation Level of Cardiac Troponin-I with Total Duration of Oxygen/ Ventilator Therapy in the Term New-borns with Respiratory Distress
|Aleksandra Simovic1,2* and Andelka Stojkovic1,2|
|1Paediatric Clinic, Kragujevac, Serbia|
|2Faculty of Medical Science, University of Kragujevac, Serbia|
|Corresponding Author :||Aleksandra Simovic
Assistant Professor, Paediatric Clinic, Clinical Centre"Kragujevac"
Faculty of Medical Science, University of Kragujevac, Zmaj Jovina 30
34000 Kragujevac, Serbia
Tel: +381 34 370097; +381 63 1623191
Fax: +381 34 370213
E-mail: [email protected]
|Received May 14, 2014; Accepted August 25, 2014; Published September 1, 2014|
|Citation: Simovic A, Stojkovic A (2014) Correlation Level of Cardiac Troponin-I with Total Duration of Oxygen/Ventilator Therapy in the Term New-borns with Respiratory Distress. J Cardiovasc Dis Diagn 2: 172. doi: 10.4172/2329-9517.1000172|
|Copyright: © 2014 Aleksandra Simovic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: In spite of its potential clinical prognostic significance, only a small number of studies have been conducted to date involving neonatal cardiac troponin-I as an early indicator of significance respiratory dysfunction.
Objective: Aim of this study was to evaluate the clinical significance cardiac troponin-I as marker of cardiorespiratory failure in term newborns. Methods: Cardiac troponin-I level was determined in serum (at 24-48 hours after birth) in 55 term neonates with respiratory distress and 36 healthy, term newborns. The cardiac troponin-I level is correlated with the total duration of oxygen and ventilatory therapy (expressed in days) in both groups with (13/55) or without (32/55) deaths.
Results: Newborns with respiratory distress had a significantly higher level of cardiac troponin-I, compared to the control group, with the largest increase in cardiac troponin-I observed in mechanically ventilated patients (31/55). The length of applied respiratory support was positively correlated with the level of cardiac troponin-I in survivors of respondents, while in the group of children who died the level of cardiac troponin-I was negatively correlated with total duration of respiratory support, and the number of days to death.
Conclusions: The increase in cardiac troponin-I could indicate the development of severe respiratory failure in term neonates with respiratory distress.