Correlation of Disease Activity, IL-6 & CRP Levels and Leukocytes/Lymphocyte Ratio Among Patients with Acute Pancreatitis
- *Corresponding Author:
- Prof. Dr. Vedat Goral
Dicle University School of Medicine
Department of Gastroenterology
Tel: 0090 412 2488443
Fax: 0090 412 2488443
E-mail: [email protected]
Received date: December 02, 2011; Accepted date: June 08, 2012; Published date: June 10, 2012
Citation: Goral V, Berekatoglu1 Mete N (2012) Correlation of Disease Activity, IL-6 & CRP Levels and Leukocytes/Lymphocyte Ratio Among Patients with Acute Pancreatitis. J Gastroint Dig Syst 2:112 doi:10.4172/2161-069X.1000112
Copyright: © 2012 Goral V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction and aim: The aim of this trial is to investigate whether the comparison of Ranson, APACHE II and Balthazar scoring systems with inflammatory mediators CRP, leukocytes/lymphocytes ratio and IL-6 are statistically significant.
Material and method: A total of 52 patients were enrolled in this trial. Ranson and APACHE II scores and serum CRP, leukocytes/lymphocytes ratio and interleukin-6 (IL-6) levels were determined in all patients. In all patients with severe AP, abdominal CT was performed in accordance with Balthazar scoring system. Results: According to correlation of AP scoring and inflammatory mediators, statistical significance was found for correlation of APACHE II with CRP and Ranson scores (P<0.001). Correlation of CRP with Ranson score and IL-6 was statistically significant (P<0.001), a significant correlation was determined between Ranson score and IL-6 (P: 0.014). Leukocytes/lypmhocyte ratio was 12.71 (1.95 ± 34.7) in patients with acute pancreatitis (normal ratio: 2.63) (P<0.001). CT examinations of severe AP cases were graded according to Balthazar scoring system; in Ranson, APACHE II scores and CRP, IL-6 values were found to be elevated, in parallel to increase in scores.
Conclusion: According to our data, we suggest using the IL-6, CRP and leukocytes/lymphocytes ratio a simple indicator of severity in patients presenting with acute pancreatitis.