Correlation of Retinal Nerve Fibre Layer Thickness with HbA1c and Oxidised LDL in Non-proliferative Diabetic RetinopathyYusof Nor-Sharina1,2, Embong Zunaina1,2*, Ismail Shatriah1,2, Kyi Win-Mar2,3 and Ab-Rahman Azriani2,4
- *Corresponding Author:
- Embong Zunaina
Department of Ophthalmology
School of Medical Sciences
Universiti Sains, Malaysia
16150 Kubang Kerian, Kelantan, Malaysia
Tel: 609 767 6362
Fax: 609 765 3370
E-mail: [email protected]
Received date: July 31, 2013; Accepted date: September 16, 2013; Published date: September 21, 2013
Citation: Nor-Sharina Y, Zunaina E, Shatriah I, Win-Mar K, Azriani AR (2013) Correlation of Retinal Nerve Fibre Layer Thickness with HbA1c and Oxidised LDL in Non-proliferative Diabetic Retinopathy. J Diabetes Metab 4:298. doi:10.4172/2155-6156.1000298
Copyright: © 2013Nor-Sharina Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: The purpose of this study is to determine the correlation of retinal nerve fibre layer (RNFL) thickness with glycosylated haemoglobin (HbA1c) and oxidised low density lipoprotein (LDL) among Type 2 non-proliferative diabetic retinopathy (NPDR).
Methodology: This is a cross-sectional study involving 125 patients with Type 2 NPDR (mild NPDR: 45 patients, moderate NPDR: 45 patients and severe NPDR: 35 patients). Patients were evaluated for peri-papillary RNFL thickness by Heidelberg Retina Tomography. Blood were taken for HbA1c and oxidised LDL.
Results: Severe NPDR showed the highest mean RNFL thickness (severe: 762.60 SD 209.57 μm, moderate: 738.24 SD 200.30 μm, mild: 700.27 SD 215.44 μm), however it was not significant (p=0.40). There was significant fair negative correlation between RNFL thickness and oxidised LDL in NPDR (r=- 0.391, p<0.001). However, there was no significant correlation between RNFL thickness and HbA1c (r=0.048, p=0.60).
Conclusion: Early NPDR appears to have thinner RNFL thickness and is significantly correlated with high level of oxidised LDL.