alexa Correlation of Retinal Nerve Fibre Layer Thickness with HbA1c and Oxidised LDL in Non-proliferative Diabetic Retinopathy
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Correlation of Retinal Nerve Fibre Layer Thickness with HbA1c and Oxidised LDL in Non-proliferative Diabetic Retinopathy

Yusof Nor-Sharina1,2, Embong Zunaina1,2*, Ismail Shatriah1,2, Kyi Win-Mar2,3 and Ab-Rahman Azriani2,4

1Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia

2Hospital Universiti Sains Malaysia, Malaysia

3Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia

4Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Malaysia

*Corresponding Author:
Embong Zunaina
Department of Ophthalmology
School of Medical Sciences
Universiti Sains, Malaysia
16150 Kubang Kerian, Kelantan, Malaysia
Tel: 609 767 6362
Fax: 609 765 3370
E-mail: [email protected]

Received date: July 31, 2013; Accepted date: September 16, 2013; Published date: September 21, 2013

Citation: Nor-Sharina Y, Zunaina E, Shatriah I, Win-Mar K, Azriani AR (2013) Correlation of Retinal Nerve Fibre Layer Thickness with HbA1c and Oxidised LDL in Non-proliferative Diabetic Retinopathy. J Diabetes Metab 4:298. doi:10.4172/2155-6156.1000298

Copyright: © 2013Nor-Sharina Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: The purpose of this study is to determine the correlation of retinal nerve fibre layer (RNFL) thickness with glycosylated haemoglobin (HbA1c) and oxidised low density lipoprotein (LDL) among Type 2 non-proliferative diabetic retinopathy (NPDR).

Methodology: This is a cross-sectional study involving 125 patients with Type 2 NPDR (mild NPDR: 45 patients, moderate NPDR: 45 patients and severe NPDR: 35 patients). Patients were evaluated for peri-papillary RNFL thickness by Heidelberg Retina Tomography. Blood were taken for HbA1c and oxidised LDL.

Results: Severe NPDR showed the highest mean RNFL thickness (severe: 762.60 SD 209.57 μm, moderate: 738.24 SD 200.30 μm, mild: 700.27 SD 215.44 μm), however it was not significant (p=0.40). There was significant fair negative correlation between RNFL thickness and oxidised LDL in NPDR (r=- 0.391, p<0.001). However, there was no significant correlation between RNFL thickness and HbA1c (r=0.048, p=0.60).

Conclusion: Early NPDR appears to have thinner RNFL thickness and is significantly correlated with high level of oxidised LDL.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version