Correlation of Retinal Vessel Analysis and Nerve Fiber Layer Thickness in Normal Tension Glaucoma
|Schallenberg M1, Kremmer S1,2, Anastassiou G1,2, Steuhl KP1 and Selbach JM1,2*|
|1Department of Ophthalmology, University Hospital Essen, Germany|
|2Department of Ophthalmology, Evangelisches Krankenhaus, Munckelstr. 27, 45879 Gelsenkirchen, Germany|
|Corresponding Author :||Michael J Selbach MD, PhD
Department of Ophthalmology
Munckelstr. 27, 45879 Gelsenkirchen, Germany
E-mail: [email protected]
|Received: October 08, 2015 Accepted: November 25, 2015 Published: November 30, 2015|
|Citation: Schallenberg M, Kremmer S, Anastassiou G, Steuhl KP, Selbach JM (2015) Correlation of Retinal Vessel Analysis and Nerve Fiber Layer Thickness in Normal Tension Glaucoma. J Clin Exp Ophthalmol 6:497. doi:10.4172/2155-9570.1000497|
|Copyright: © 2015 Schallenberg M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: To investigate the retinal vessel diameter and its possible relationship with the retinal nerve fiber layer (RNFL) thickness in normal tension glaucoma (NTG).
Methods: 86 NTG patients with detailed eye examination including retinal vessel analysis (DVA) and measurement of the RNFL thickness with scanning laser polarimetry (SLP; GDxVCC) were included in this retrospective study. The temporal retinal arteriolar diameters, temporal retinal venular diameters, vascular flicker response were compared with RNFL thickness and NFI (nerve fiber index).
Results: The flicker response of DVA was significantly reduced as compared to normal eyes. The diameters of the temporal retinal arteriolar vessels were significantly correlated with RNFL thickness (P=0.0204) and NFI of GDxVCC (P=0.0021). The diameters of the temporal retinal venular were significantly correlated with the NFI (P=0.0298).
Conclusion: Our results show that narrower arteriolar vessels are found in advanced NTG patients. These findings may be due to the decreased demand for retinal blood flow in damaged retina, but also may be one reason for the damage. Vessel analysis can contribute to the available tools predicting glaucomatous damage before visual field loss becomes manifest.