Correlation of the Imaging Findings with Bronchoscopic Findings for the Detection of Endobronchial Lesions: A Systematic Review and Meta-Analysis
Marousa Kouvela*, Sotirios Kakavas, Christos Karetsos and Evangelos Balis
Department of Pulmonary Medicine, Evangelismos Hospital, Athens, Greece
- *Corresponding Author:
- Marousa Kouvela
Department of Pulmonary Medicine, Evangelismos Hospital
E-mail: [email protected]
Received date: January 09, 2017; Accepted date: February 17, 2017; Published date: February 21, 2017
Citation: Kouvela M, Kakavas S, Karetsos C, Balis E (2017) Correlation of the Imaging Findings with Bronchoscopic Findings for the Detection of Endobronchial Lesions: A Systematic Review and Meta-Analysis. J Pulm Respir Med 6:395. doi: 10.4172/2161-105X.1000395
Copyright: © 2017 Kouvela M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: The purpose of this systematic review was to compare the diagnostic accuracy of axial thoracic CT, other imaging techniques and image reconstruction algorithms with the endoscopic findings of Fiberopptic Bronchoscopy (FOB), in patients with newly detected endobronchial lesions.
Methods: A systematic review of the literature for retrospective and prospective studies was performed. Articles considered included patients with endobronchial stenosis that were subjected to axial Computed Tomography of the chest with or without an image reconstruction technique, and Fiberoptic Bronchoscopy.
Results: 10 studies (6 prospective/4 retrospective) that were published in PubMed or CancerLit met the inclusion criteria. A total number of 633 patients were involved in the studies and an additional number of 53 patients were included as controls. All the patients were subjected to Fiberoptic Bronchoscopy (FOB) and imaging of the chest. The meta-analysis showed a high sensitivity for most imaging techniques, comparable with this of Fiberoptic Bronchoscopy, but with a significant Negative Predictive Value.
Conclusion: Even though the imaging techniques are a useful, fast and safe modality for the detection of endobronchial lesions, the high negative predictive value raises a concern on their sufficiency for the exclusion of lung cancer on high risk patients.