alexa Cost-effectiveness Analysis of Insulin Detemir Compared to Neutral Protamine Hagedorn (NPH) in Patients with Type 1 and Type 2 Diabetes Mellitus in Portugal
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Cost-effectiveness Analysis of Insulin Detemir Compared to Neutral Protamine Hagedorn (NPH) in Patients with Type 1 and Type 2 Diabetes Mellitus in Portugal

Cristina Cardoso1, Antonio Ramírez de Arellano2*, Miriam Prades3 and Luis Lizan3

1Novo Nordisk, Lisbon, Portugal

2Health Economics and Outcomes Research Europe, Novo Nordisk, Madrid, Spain

3Outcomes’10, Universidad Jaume I, Castellon, Spain

Corresponding Author:
Dr. Antonio Ramirez de Arellano
Novo Nordisk Pharma, S.A. Via de los Poblados
3 Parque Empresarial Cristalia, Edificio 6 – 4a Planta
28033 Madrid, Spain
Tel: 913379800
E-mail: [email protected]

Received Date: December 28, 2015; Accepted Date: March 03, 2016; Published Date: March 10, 2016

Citation: Cardoso C, de Arellano AR, Prades M, Lizan L (2016) Cost-effectiveness Analysis of Insulin Detemir Compared to Neutral Protamine Hagedorn (NPH) in Patients with Type 1 and Type 2 Diabetes Mellitus in Portugal. J Diabetes Metab 7:653. doi:10.4172/2155-6156.1000653

Copyright: © 2016 Cardoso C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: To estimate the short-term (1 year) cost-effectiveness of Insulin Detemir (IDet) compared with Neutral Protamine Hagedorn (NPH) insulin for Type 1 (T1DM) and Type 2 Diabetes Mellitus (T2DM) in Portugal. Methods: A short-term cost-effectiveness model was adapted to the Portuguese National Health System (NHS), to estimate the Incremental Cost-Effectiveness Ratio (ICER) of IDet vs. NPH in terms of euros per quality-adjusted life years (€/QALY) gained. Non-severe hypoglycemia (NSH) rate for both diabetes types, and weight change, only for T2DM, were the clinical benefit variables. Three scenarios were estimated in which NPH was assigned three different values corresponding to a cohort of recent insulinization and a cohort of long-run insulinization from the UK Hypoglycemia Study and from a Spanish observational study. For all scenarios, the hypoglycemia Rate Ratio (RR) for T1DM was based on the CADTH Technology Report while for T2DM it was based on the head-to-head NCT00104182 randomized clinical trial. For T2DM, weight gain was also included in the model, based on the same RCT. Disutility values to calculate quality-adjusted life years (QALYs) were associated to NSH events and to BMI unit gain. Costs (Euros 2014), estimated from the perspective of the Portuguese NHS, included only insulin treatment and mild hypoglycemia management. Results: For the three scenarios a range of 0.025 – 0.076 QALYs for T1DM and 0.014 – 0.051 QALYs for T2DM were gained for IDet vs. NPH due to NSH and weight gain avoidance, in return of an incremental cost of €159.38 - €248.98 for T1DM and €209.66 – €274.44 for T2DM. This resulted in IDet vs. NPH ICER ranging between €2,096.23 and €9,936.98/QALY for T1DM and €4,145.75 and €19,999.87/QALY for T2DM. Conclusions: IDet appears as a cost-effective alternative to NPH in Portugal for T1DM and T2DM in all considered scenarios due to lower hypoglycemic rate and less weight gain.


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