alexa Cost-Minimization Analysis of Linagliptin Compared to Sitagliptin in the Treatment of Type 2 Diabetes Mellitus from a Turkish Healthcare Perspective
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Research Article

Cost-Minimization Analysis of Linagliptin Compared to Sitagliptin in the Treatment of Type 2 Diabetes Mellitus from a Turkish Healthcare Perspective

Ergun Oksuz1, Simten Malhan2, Begum Urgancı3 and Erkan Tetik3

1Baskent University, Faculty of Medicine, Department of Family Medicine, Ankara, Turkey

2Baskent University, Faculty of Health Sciences, Ankara, Turkey

3Boehringer Ingelheim, Istanbul, Turkey

*Corresponding Author:
Dr Ergun Oksuz, MD
Professor, Baskent University
Faculty of Medicine, Department of Family Medicine
Ankara, Turkey
Tel: +903122466773
E-mail: [email protected]

Received date: April 21, 2017; Accepted date: May 03, 2017; Published date: May 10, 2017

Citation: Oksuz E, Malhan S, Urganci B, Tetik T (2017) Cost-Minimization Analysis of Linagliptin Compared to Sitagliptin in the Treatment of Type 2 Diabetes Mellitus from a Turkish Healthcare Perspective. J Diabetes Metab 8:739. doi: 10.4172/2155-6156.1000739

Copyright: © 2017 Oksuz E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: The aim of the present study is to evaluate linagliptin and sitagliptin in terms of pharmacoeconomics, by comparing the two dipeptidyl-peptidase 4 inhibitors (DPP-4i) with cost-minimization analysis. Methods: Cost-minimization analysis was used to compare linagliptin and sitagliptin in terms of pharmacoeconomics. In a recent meta-analysis, linagliptin and sitagliptin were reported to have similar effects regarding the reduction in the HbA1c levels achieved at the 24th week of treatment (HbA1c reduction at 24th week: -0.8%). Direct medical costs in Turkey were used for the comparisons. Cost data was constituted from the perspective of the healthcare payer, taking alternative therapies and all possible complications into consideration, and reviewing actual data from a tertiary healthcare center, related literature and clinical guidelines. A model was established with Microsoft Office Excel 2015 software, using the local data specifically from diabetes (DM) patients. Cost analysis was performed for one-year time frame. Results: Average direct annual treatment cost per patient in type 2 diabetes mellitus (T2DM) was € 1,481.4 with linagliptin and € 1,500.1 with sitagliptin. In comparison to sitagliptin, linagliptin is determined to be a cost-saving alternative (- € 18.7). Probabilistic sensitivity analysis with Monte Carlo Simulation showed that linagliptin treatment (95% confidence interval € 1,393.8- € 1,523.9; n=1,000) is 52.9% equal or cost-saving compared to sitagliptin treatment (95% confidence interval € 1,380.5- € 1,509.1; n=1,000). Conclusion: From the healthcare payer's perspective in Turkey regarding treatment of T2DM, linagliptin, a DPP-4 inhibitor, is a cost-saving treatment alternative to sitagliptin, with both having similar effects on HbA1c levels.


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