Could Serum Testosteron Level and Body Mass Index Predict Psa Relaps in Prostate Cancer Patients undergoing Radical Surgery?
Adnan Simsir, Cag Cal*, Rashad Mammadov, Ibrahim Cureklibatir and Gurhan Gunaydin
Ege University School of Medicine, Department of Urology, Izmir, Turkey
- *Corresponding Author:
- Adnan Simsir
EÜTF Hastanesi 4. kat Üroloji AD
Bornova Izmir, Turkey
Tel: +90 232 390 25 17
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E-mail: [email protected]
Received Date: October 06, 2011; Accepted Date: November 17, 2011; Published Date: November 19, 2011
Citation: Simsir A, Cal C, Mammadov R, Cureklibatir I, Gunaydin G (2011) Could Serum Testosteron Level and Body Mass Index Predict Psa Relaps in Prostate Cancer Patients undergoing Radical Surgery? J Cancer Sci Ther S1:007. doi: 10.4172/1948-5956.S1-007
Copyright: © 2011 Simsir A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: It is well-known that indicators such as biopsy and prostatectomy Gleason score , clinical and pathological stage and preoperative PSA level can be utilized in predicting PSA recurrence in cases who underwent radical prostatectomy (RP) with the diagnosis of organ-confined prostate cancer. The purpose of this study was to investigate the predictability of postoperative PSA recurrence by serum total testosterone levels as well as body mass index (BMI).
Materials and methods: Fourty-eight patients in whom RP was planned with the diagnosis of prostate-confined cancer were enrolled in this study. The data recorded included the patient’s preoperative testosterone levels and BMI as well as age, serum PSA level, clinical stage, Gleason score on biopsy, the presence of PIN and surgical margin positivity. After operation, the patients were kept under follow up according to the guidelines. During the follow-up, the analysis of the selected markers was performed using T-test, Mann-Whitney U test, Chi square test, Anova and Roc analysis in cases with documented PSA recurrence.
Results: Serum total testosterone level, BMI, surgical margin positivity and Gleason score and preoperative PSA level are independent variables that affect PSA recurrence. On Roc analysis, a testosterone level of less than 2,81 ng/dL was found to be significant for the prediction of PSA recurrence (p=0.04).
Conclusion: From this study, we concluded that, besides proven risk factors for PSA recurrence (Pre op. PSA level, Gleason score, surgical margin positivity and stage), preoperative low testosterone levels and high BMI can also be predictive.