alexa CPAP with Pressure Relief during Exhalation (C-Flex+) is as Effective as CPAP in the Treatment of Obstructive Sleep Apnea | OMICS International | Abstract
ISSN: 2167-0277

Journal of Sleep Disorders & Therapy
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Research Article

CPAP with Pressure Relief during Exhalation (C-Flex+) is as Effective as CPAP in the Treatment of Obstructive Sleep Apnea

Monika Krawietz1, Carmen Garcia1, Carsten Pilz1, Martin Glos1, Beate Diecker1, Ingo Fietze1 and Thomas Penzel1,2*

1Charité University Medicine Berlin, Berlin, Germany

2International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic

Corresponding Author:
Thomas Penzel
Sleep Medicine Center, Charité - University Medicine Berlin, Berlin, Germany
Tel: 4930450513122
E-mail: [email protected]

Received Date: May 03, 2017; Accepted Date: May 14, 2017; Published Date: May 19, 2017

Citation: Krawietz M, Garcia C, Pilz C, Glos M, Penzel T, et al. (2017) CPAP with Pressure Relief during Exhalation (C-Flex+) is as Effective as CPAP in the Treatment of Obstructive Sleep Apnea. J Sleep Disord Ther 6:268 doi: 10.4172/2167-0277.1000268

Copyright: © 2017 Krawietz M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Purpose: Continuous positive airway pressure (CPAP) is the accepted therapy for obstructive sleep apnea (OSA). An expiratory pressure relief technology called C-Flex+ has been developed to improve the comfort of CPAP therapy. It provides a 2 mbar lower exhalation pressure and an additional flow-based pressure relief at the beginning of exhalation. The following study was conducted to investigate whether C-Flex+ was as effective as CPAP in treating OSA, and the patients’ preference.

Methods: 60 newly diagnosed patients with OSA completed this double-blind controlled crossover-study. Patients were randomized to one night of C-Flex+ and one of CPAP under full attended polysomnography (PSG). A comfort visual analog scale (VAS) ranging from 0 to 10, with 10 being the highest comfort, was completed by all patients immediately after each PSG.

Results: There was no significant difference between the therapy modes in the apnea/hypopnea index (median 1.5 events/hour (h) with C-Flex+ (interquartile range (IQR) 0.7 to 3.6) vs. 1.7 events/h with CPAP (IQR 0.8 to 3.8), p=0.178). The sleep efficiency, sleep architecture and nocturnal oxygenation were also comparable. Most patients preferred C-Flex+ over CPAP (65%, p<0.001). C-Flex+ earned significantly higher ratings in the VAS (8.1 (7.2 to 9.0) vs. 7.0 (5.1 to 8.8), p<0.001).

Conclusion: C-Flex+ was as effective as CPAP therapy in treating OSA and patients preferred this mode of therapy.


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