alexa Critical Illness and the Aging Population: Clinical Imp
ISSN: 2329-6895

Journal of Neurological Disorders
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Critical Illness and the Aging Population: Clinical Implications and Pharmacotherapy Challenges

Gretchen M. Brophy1*, Catherine K. Floroff2, Spencer E. Harpe3and Patricia W4
1Department of Pharmacotherapy and Outcomes Science and Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
2Medical University of South Carolina, South Carolina College of Pharmacy, 280 Calhoun Street, MSC 132, Charleston, SC, USA
3Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, USA
4Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA
Corresponding Author : Gretchen M Brophy
Professor of Pharmacotherapy and Outcomes Science and Neurosurgery
Virginia Commonwealth University, 410 N. 12th Street
Room 642, Richmond, VA, USA
Tel: (804)828-1201
Fax: (804) 828-0343
E-mail: [email protected]
Received December 09, 2014; Accepted December 16, 2014; Published December 18, 2014
Citation:Brophy GM, Floroff CK, Harpe SE, Patricia W (2015) Critical Illness and the Aging Population: Clinical Implications and
Pharmacotherapy Challenges. J Neurol Disord 3:197. doi: 10.4172/2329-6895.1000197
Copyright: ©2015 Gretchen M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

The rate of critically ill older patients being admitted to intensive care units (ICU) continues to rise. Multiple factors influence the complexity of treatment strategies and create challenges for optimizing patient care while avoiding unwanted adverse effects. These factors include Pharmacokinetic (PK) and Pharmacodynamics (PD) changes that are compounded by both age and critical illnesses and may heighten the risk of suboptimal treatment strategies and adverse drug events, including neurotoxicity, to the patient. Medications that increase the risk for adverse drug events, drug-drug interactions, and drug-disease interactions may be classified as a potentially inappropriate medications based on risk versus benefit of use in older adults. However, many times these agents are needed for treatment of critically ill patients and must be dosed and monitored appropriately to avoid complications, such as delirium, which is associated with increased morbidity and mortality in the older population. Unfortunately, clinical pharmacotherapy and outcome studies with extreme age considerations for pharmacotherapy are lacking. This article reviews the pharmacotherapy challenges in older critically ill patients, and provides medication considerations for avoiding adverse drug events that may complicate patient care.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords