alexa Critical Illness and the Aging Population: Clinical Imp
ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Critical Illness and the Aging Population: Clinical Implications and Pharmacotherapy Challenges

Gretchen M. Brophy1*, Catherine K. Floroff2, Spencer E. Harpe3and Patricia W4
1Department of Pharmacotherapy and Outcomes Science and Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
2Medical University of South Carolina, South Carolina College of Pharmacy, 280 Calhoun Street, MSC 132, Charleston, SC, USA
3Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, USA
4Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA
Corresponding Author : Gretchen M Brophy
Professor of Pharmacotherapy and Outcomes Science and Neurosurgery
Virginia Commonwealth University, 410 N. 12th Street
Room 642, Richmond, VA, USA
Tel: (804)828-1201
Fax: (804) 828-0343
E-mail: [email protected]
Received December 09, 2014; Accepted December 16, 2014; Published December 18, 2014
Citation:Brophy GM, Floroff CK, Harpe SE, Patricia W (2015) Critical Illness and the Aging Population: Clinical Implications and
Pharmacotherapy Challenges. J Neurol Disord 3:197. doi: 10.4172/2329-6895.1000197
Copyright: ©2015 Gretchen M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The rate of critically ill older patients being admitted to intensive care units (ICU) continues to rise. Multiple factors influence the complexity of treatment strategies and create challenges for optimizing patient care while avoiding unwanted adverse effects. These factors include Pharmacokinetic (PK) and Pharmacodynamics (PD) changes that are compounded by both age and critical illnesses and may heighten the risk of suboptimal treatment strategies and adverse drug events, including neurotoxicity, to the patient. Medications that increase the risk for adverse drug events, drug-drug interactions, and drug-disease interactions may be classified as a potentially inappropriate medications based on risk versus benefit of use in older adults. However, many times these agents are needed for treatment of critically ill patients and must be dosed and monitored appropriately to avoid complications, such as delirium, which is associated with increased morbidity and mortality in the older population. Unfortunately, clinical pharmacotherapy and outcome studies with extreme age considerations for pharmacotherapy are lacking. This article reviews the pharmacotherapy challenges in older critically ill patients, and provides medication considerations for avoiding adverse drug events that may complicate patient care.

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