alexa CrohnÂ’s Disease and Mucocutaneous Conditions
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

CrohnÂ’s Disease and Mucocutaneous Conditions

Toshiyuki Yamamoto*

Department of Dermatology, Fukushima Medical University, Fukushima, Japan

*Corresponding Author:
Dr. Toshiyuki Yamamoto
Department of Dermatology
Fukushima Medical University, Hikarigaoka 1
Fukushima 960-1295, Japan
E-mail: [email protected]

Received date: July 12, 2011; Accepted date: October 17, 2011; Published date: October 20, 2011

Citation: Yamamoto T (2011) Crohn's Disease and Mucocutaneous Conditions. J Clin Exp Dermatol Res S2:001. doi: 10.4172/2155-9554.S2-001

Copyright: © 2011 Yamamoto T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Crohn’s disease is an immune-mediated disorder. Tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) produced by Th1 lymphocytes have traditionally been shown to be important in the pathogenesis of Crohn’s disease. In addition, recent studies demonstrate more complex cytokine networks, in which Th17 cells play a central role. The expansion and maintenance of Th17 cell responses require the activity of interleukin-23 (IL-23), and thus IL-23/IL-17 axis has been suggested to play a major role in the pathogenesis of Crohn’s disease. Crohn’s disease presents with various mucocutaneous signs, some of which show similar histological features of non-caseating granulomas with multinucleated histiocytes. Specific mucocutaneous manifestations include metastatic (cutaneous) Crohn’s disease,
perianal fistula, and oral Crohn’s disease. Although not specific, other various manifestations which histologically show granulomatous conditions are sometimes associated with Crohn’s disease. Also, Crohn’s disease exhibits other organ manifestations such as joints, eyes, kidneys, liver and biliary tracts, and vasculature. Those disorders may share pathognomonic significance attributed to common or similar mechanisms. The efficacy of TNF-targeting therapies strongly suggests the pivotal role of TNF-α in Crohn’s disease. Anti-TNF therapies bring beneficial effects for not only intestinal, but also mucocutaneous, joint, and ocular involvements. In this review, recent insights of the pathogenesis of Crohn’s disease, as well as mucocutaneous manifestations associated with Crohn’s disease, are introduced.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version