CSF and Neuropsychological Correlates of Visual Hallucination in Dementia with Lewy BodiesWilliam T Hu*, Manuel Hazim, Chadwick M Hales, James L Lah and Allan I Levey
Department of Neurology, Emory University, Atlanta, USA
- Corresponding Author:
- William Hu
Department of Neurology
Emory University 615 Michael Street
505F Atlanta, GA 30322, USA
E-mail: [email protected]
Received date: July 28, 2014; Accepted dat: October 13, 2014,; Published date: October 20, 2014
Citation: Hu WT, Hazim M, Hales CM, Lah JL, Levey AI (2014) CSF and Neuropsychological Correlates of Visual Hallucination in Dementia with Lewy Bodies. J Neurol Neurophysiol 5:238. doi:10.4172/2155-9562.1000238
Copyright: © 2014 Hu WT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To identify clinical features of dementia with Lewy bodies (DLB) least likely associated with
Alzheimer's disease pathology, and to determine whether it is associated with a unique neuropsychological profile.
Methods: Clinical records of 98 patients given the diagnosis of DLB at a specialty cognitive and behavioral
neurology clinic in a tertiary referral center were retrospectively reviewed for core, suggestive, and supportive
features of DLB as well as demographic variables, cerebrospinal fluid (CSF) Alzheimer's biomarkers, and
longitudinal neuropsychological analyses.
Results: Core, suggestive, and supportive features were common in this cohort, with 69% and 39% of patients
assigned the diagnosis of probable DLB and possible DLB fulfilling consensus criteria for probable DLB. 26 of 98
clinically diagnosed DLB patients had CSF Alzheimer's biomarker analysis, and visual hallucination was the only
feature not associated with CSF suggestive of Alzheimer's disease. 42 of 98 patients had longitudinal
neuropsychological analyses, and patients with visual hallucinations had worse baseline executive functions but
slower longitudinal decline in executive functions than patients without visual hallucinations.
Conclusion: Visual hallucination in clinically diagnosed DLB is associated with CSF biomarkers consistent with a
non-AD disorder and a unique longitudinal neuropsychological profile. DLB patients with visual hallucinations can be
considered a unique DLB endophenotype for future biomarker discovery and validation.