alexa Current Advancements on the Significance of Oncolytic V
ISSN: 2157-7579

Journal of Veterinary Science & Technology
Open Access

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Review Article

Current Advancements on the Significance of Oncolytic Viruses in the Treatment of Tumor Cells

Addisu Demeke*, Asmelash Tassew and Aklilu Feleke

Department of Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Debre Zeit, Ethiopia

*Corresponding Author:
Addisu Demeke
Department of Microbiology
Immunology and Public Health
College of Veterinary Medicine and Agriculture
Addis Ababa University, Debre Zeit, Ethiopia
Tel: +251-111-239746
E-mail:
[email protected]

Rec date: Dec 28, 2015; Acc date: Feb 04, 2016; Pub date: Feb 06, 2016

Citation: Demeke A, Tassew A, Feleke A (2016) Current Advancements on the Significance of Oncolytic Viruses in the Treatment of Tumor Cells. J Veterinar Sci Technol 7:308. doi:10.4172/2157-7579.1000308

Copyright: © 2016 Demeke A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The occurrence and severity of tumor, which is caused by many factors and etiological agents, become rapid and its distribution is worldwide that lead to death of many individuals. In order to avoid associated complications scientists discovered a means for the removal of tumor using oncolytic virus called virotherapy. This review is aiming to give highlight about the current advancements on the significance of oncolytic viruses in the treatment of tumor cells. Oncolytic viruses carry the promise to efficiently target cancer cells for destruction and spread throughout tumor tissue to reach distant loci without causing collateral damage to healthy tissues. Current oncolytic virotherapy strategies are based on the common molecular mechanisms of viral infection and cell transformation, like apoptotic dysregulation and cell cycle disruption. In this regards this time scientists is being done active research to improve the accessibility, safety and efficacy of oncolytic virotherapy.

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