alexa Current Evidence on the Association between Four Polymo
ISSN: 2380-2391

Journal of Environmental Analytical Chemistry
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Research Article

Current Evidence on the Association between Four Polymorphisms in the Matrix Metalloproteinases (MMP) Gene and Breast Cancer Metastasis

Pan Xiangpo1, Liu Shuzhen1, Gao Jianfeng1, Liu Haiyu2, Ren Haipeng1, Wang Huanxin1, Zheng Dejie1, Yang Baohog1*, Yang Jinhong1 and Yu Guohua1*

1Wei Fang people`s Hospital, Yu he road 151#, Kui Wen district, Weifang city, Shandong Province, China

2Ping Du people`s Hospital, Hong qi road 15#, Ping Du city, Shandong Province, China

*Corresponding Author:
Yang Baohong
Wei Fang People`s Hospital
Yu he road 151#, Kui Wen district
Weifang city, Shandong Province, China
Tel: 857996032
E-mail: [email protected]
Yu Guohua
Wei Fang People`s Hospital
Yu he road 151#, Kui Wen district
Weifang city, Shandong Province, China
Tel: 857996032
E-mail: [email protected]

Received date: July 03, 2015; Accepted date: July 28, 2015; Published date: August 07, 2015

Citation: Xiangpo P, Shuzhen L, Jianfeng G, Haiyu L, Haipeng R, et al. (2015) Current Evidence on the Association between Four Polymorphisms in the Matrix Metalloproteinases (MMP) Gene and Breast Cancer Metastasis. J Environ Anal Chem 2:151. doi: 10.4172/2380-2391.1000151

Copyright: © 2015 Xiangpo P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The matrix metalloproteinases (MMP) can degrade various components of the extracellular matrix and its functional genetic polymorphisms may be associated with cancer metastasis. However, this relationship remains inconclusive in breast cancer. To better understand the roles of MMP polymorphisms in breast cancer metastasis, we conducted this comprehensive meta-analysis encompassing 1,165 cases and 3,418 controls. Four polymorphisms including MMP1 (-1607 1G/ 2G), MMP2 (-1575 G.A), MMP3 (1612 5A/6A), and MMP9 (-1562 C.T) were studied in this meta-analysis. Crude odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of association. We found significant association between MMP1 (-1607 1G/2G) and breast cancer metastasis (for the recessive model 2G/2G vs. 1G/2G+1G/1G: OR 1.81, 95% CI 1.32–2.48; for the dominant model 2G/2G+1G/2G vs. 1G/1G: OR 1.60, 95% CI 1.02– 2.50). For the MMP3, significant association between MMP3 (-1171 5A/6A) and breast cancer metastasis was also detected under the dominant model (6A/6A+5A/6A vs. 5A/5A: OR 0.55, 95% CI 0.37-0.80). In conclusion, our results demonstrate that MMP1 may contribute the risk of breast cancer metastasis, while MMP3 played a protective role in breast cancer metastasis. Further studies are needed to evaluate these associations with breast cancer metastasis.

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