Current Evidence on the Association between Mmp-7 (-181a>G) Polymorphism and Digestive System Cancer Risk
Pan Ke, Zhong De Wu, Hua Song Wen, Miao Xiong Ying, Huo Cheng Long and Liu Guo Qing*
Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University, Chang-Sha, Hunan Province, China
- Corresponding Author:
- Guo Qing Liu
Department of General Surgery
Xiang-Ya 2nd Hospital, Central South University
Chang-Sha, Hunan Province, China
E-mail: [email protected]
Received: February 28, 2013; Accepted: March 29, 2013; Published: April 02, 2013
Citation: Ke P, De Wu Z, Wen HS, Ying MX, Long HC, et al. (2013) Current Evidence on the Association between Mmp-7 (-181a>G) Polymorphism and Digestive System Cancer Risk. J Bioanal Biomed S9:001. doi:10.4172/1948-593X.S9-001
Copyright: © 2013 Ke P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The matrix metalloproteinase (MMPs) can degrade various components of the extracellular matrix and its
functional genetic polymorphisms may contribute to genetic susceptibility to many cancers. Up to now, the association between MMP-7 (-181A>G) and digestive system cancer risk remain inconclusive. To better understand the role of MMP-7 (-181A>G) genotype in digestive cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher digestive system cancer risk in homozygote comparison (GG vs. AA, OR=1.21, 95% CI=1.12-1.60) and dominant model (GG/GA vs. AA, OR=1.16, 95% CI=1.03-1.46). In subgroup analysis, this polymorphism was significantly linked to higher risks for gastric cancer (GG vs. AA, OR=1.22, 95% CI=1.02-1.46; GA vs. AA, OR=1.82, 95% CI=1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI=1.01-1.27; GG vs. GA/AA, OR=1.25, 95% CI=1.06-2.39. We also observed increased susceptibility of colorectal cancer and ESCC in homozygote comparison (OR=1.13, 95% CI=1.06-1.26) and heterozygote comparison (OR=1.45, 95% CI=1.11-1.91) respectively. In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08- 1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12-1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for digestive system cancer, especially among Asian population.