alexa Current Perspectives on Pathobiology of the Ductus Arteriosus
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

Current Perspectives on Pathobiology of the Ductus Arteriosus

Jason Z. Stoller1*, Sara B. DeMauro1, John M. Dagle2 and Jeff Reese3
1Department of Pediatrics, University of Pennsylvania School of Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
2Departments of Pediatrics and Biochemistry, University of Iowa, Iowa City, IA 52242, USA
3Departments of Pediatrics, and Cell and Developmental Biology; Vanderbilt University, Nashville, TN, 37232, USA
Corresponding Author : Jason Z. Stoller, MD
Division of Neonatology
Department of Pediatrics
University of Pennsylvania School of Medicine
Children’s Hospital of Philadelphia 3615 Civic Center Blvd
Suite 416F Philadelphia, PA 19104, USA
Tel: 215.590.4393
E-mail: [email protected]
Received November 03, 2011; Accepted January 05, 2012; Published June 15, 2012
Citation: Stoller JZ, DeMauro SB, Dagle JM, Reese J (2012) Current Perspectives on Pathobiology of the Ductus Arteriosus. J Clin Exp Cardiolog S8:001. doi: 10.4172/2155-9880.S8-001
Copyright: © 2012 Stoller JZ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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Abstract

The ductus arteriosus shunts blood away from the lungs during fetal life, but at birth this shunt is no longer needed and the vessel rapidly constricts. Postnatal persistence of the DA, patent ductus arteriosus (PDA), is predominantly a detrimental condition for preterm infants but is simultaneously a condition required to maintain systemic blood flow for infants born with certain severe congenital heart defects. Although PDA in preterm infants is associated with significant morbidities, there is controversy regarding whether PDA is truly causative. Despite advances in our understanding of the pathobiology of PDA, the optimal treatment strategy for PDA in preterm infants is unclear. Here we review recent studies that have continued to elucidate the fundamental mechanisms of DA development and pathogenesis.

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