Shiga toxin producing Escherichia coli (STEC) is a newly emerged pathogen has gained immense attention across the globe. It causes large scale epidemics and thousands of sporadic cases of diarrheal illness every year. STEC infections have been reported across the world and causes mild illness to severe bloody diarrhoea and even lifethreatening complications such as HUS in humans. The serotype O157:H7 has recently become a public-health problem of serious concern as it targets infants and young children. The review here describes the epidemiology of STEC in Indian subcontinent.