alexa Current Status of Potent Bone Resorption Antagonists
ISSN: 2329-9509

Journal of Osteoporosis and Physical Activity
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Commentary

Current Status of Potent Bone Resorption Antagonists

Ping-Chung Leung1-4*
1Jockey Club Centre for Osteoporosis Care & Control, The Chinese University of Hong Kong, China
2Professor Emeritus, Orthopaedics & Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
3State Key Laboratory of Phytochemsitry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, Hong Kong, China
4Institute of Chinese Medicine, The Chinese University of Hong Kong, China
Corresponding Author : Ping Chung Leung
5/F School of Public Health Building
Prince of Wales Hospital, Shatin, Hong Kong, China
Tel: (852) 2252 8868
Fax: (852) 2632 5441
E-mail: [email protected]
Received January 08, 2015; Accepted February 05, 2015; Published February 12, 2015
Citation: Leung PC (2015) Current Status of Potent Bone Resorption Antagonists. J Osteopor Phys Act 3:129. doi: 10.4172/2329-9509.1000129
Copyright: © 2015 Bcheraoui CEl, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

    Since osteoporosis is considered as an important risk factor to the development of bone fractures, the search for effect therapeutic agents for its prevention and maintenance has never stopped. From hormonal replacement, promotion of bone formation, to prevention of bone resorption has all been tried. The most active part has been played by the antiresorptive agents, viz the Bisphosphonates.

    Large investments in research have increased the potency of the drug hundreds of folds and remarkably secured a very effective patient compliance to once a year injection. The therapeutic triumph is complicated with serious though infrequent adverse effects with prolonged or high dose administrations. It is therefore appropriate time to realize the exact safety, the favorable dosages, and the duration of treatment of bisphosphonates. Several extended studies on bisphosphonates have given the answers. Bisphosphonate are safe and effective, serious adverse effects are rare and may occur only after prolonged use. Bisphosphonates should be used as preventive agent only for the extreme high risk cases. Preventive therapy could be safer if 3 years of administration could be followed by a rest period of 2-3years.

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