alexa Current Understanding of Epidemiology, Genetic Etiology and Treatment of Gliomas from Indian Population
ISSN: 2167-7700

Chemotherapy: Open Access
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Review Article

Current Understanding of Epidemiology, Genetic Etiology and Treatment of Gliomas from Indian Population

Rajib Mukherjee1, Tapas K Das1 ,Kaushik Roy1 and Joydeep Mukherjee2*

1Government Hospital, Kolkata, West Bengal, India

2Brain Tumor Research Centre, Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Centre, University of California-San Francisco (UCSF), San Francisco, CA 94158, USA

*Corresponding Author:
Joydeep Mukherjee
Brain Tumor Research Centre
Helen Diller Family Comprehensive Cancer Centre
University of California-San Francisco
(UCSF), HD-431, 1450, 3rd Street, San Francisco
CA 94158, USA
Tel: 415-502-7132
E-mail: [email protected]

Received date: February 18, 2016; Accepted date: May 09, 2016; Published date: May 18, 2016

Citation: Mukherjee R, Das TV, Roy K, Mukherjee J (2016) Current Understanding of Epidemiology, Genetic Etiology and Treatment of Gliomas from Indian Population. Chemo Open Access 5: 203. doi:10.4172/2167-7700.1000203

Copyright: © 2016 Mukherjee R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

 

Tumors of the central nervous system (CNS) consist of 1-2% of the total cancer spectrum. Gliomas are the most common tumors within the CNS. These tumors originate from glial cells or glial precursor cells. Tumors originates from astroglial cells are known as astrocytoma, oligodendroglioma originates from oligodendroglial cells, oligoastrocytoma are mixed tumor containing cellular property of both astrocytes and oligodendrocytes and ependymal cells gives rise to ependymoma. The World Health Organization (WHO) classification of central nervous system tumors separates glioma into four grades, in which grade I and II are defined as low grade whereas grade III and IV are classified as high grade (also known as malignant glioma). Malignant glioma includes anaplastic glioma (anaplastic oligodendroglioma, anaplastic astrocytoma, and anaplastic oligoastrocytoma) and glioblastoma. With current treatment modality, survival of patients with newly diagnosed glioblastoma is around 12–16 months. The treatment strategy includes surgery followed by adjuvant radiation and chemotherapy. From 2005, a secondgeneration oral alkylating agent known as Temozolomide (TMZ) became standard of care in the treatment of malignant glioma patients worldwide including India. In this current review, we focused on epidemiology, molecular biology and management of gliomas emerged from India.

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