alexa Currently Applied Clinical Naturopathy and Phytotherapy–Keystone for Disease Prevention and Therapy
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Short Communication

Currently Applied Clinical Naturopathy and Phytotherapy–Keystone for Disease Prevention and Therapy

Raphael Richard Ciuman*
Department of Otorhinolaryngology, Head and Neck Surgery, Marienhospital Gelsenkirchen, Germany
Corresponding Author : Dr. RR Ciuman, MD, MSc PM
Department of Otorhinolaryngology, Head and Neck Surgery
Marienhospital Gelsenkirchen, Germany
Uranusbogen 15, 45478 Mülheim
E-mail: [email protected]
Received August 28, 2013; Accepted October 07, 2013; Published October 10, 2013
Citation: Ciuman RR (2013) Currently Applied Clinical Naturopathy and Phytotherapy–Keystone for Disease Prevention and Therapy. Med Aromat Plants 2:137. doi:10.4172/2167-0412.1000137
Copyright: © 2013 Ciuman RR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cancer is a major cause of death worldwide and angiogenesis is critical in cancer progression. Development of new blood vessels and nutrition of tumor cells are heavily dependent on angiogenesis. Thus, angiogenesis inhibition might be a promising approach for anticancer therapy. Anti-angiogenic small molecule and phytochemicals as a cancer treatment approach are focused in these main points; modes of action, adverse effects, mechanisms of resistance and new developments. Treatment with anti-angiogenic compounds might be advantageous over conventional chemotherapy due to the fact that those compounds mainly act on endothelial cells, which are genetically more stable and homogenous compared to tumor cells and they show lower susceptibility to acquired drug resistance (ADR). Targeting the VEGF (vascular endothelial growth factor) signalling pathway with synthetic small molecules inhibiting Receptor Tyrosine Kinases (RTKs) in addition to antagonizing VEGF might be a promising approach. Moreover, beneficial effect of phytochemicals were proven on cancer-related pathways especially concerning anti-angiogenesis. Plant phenolics being an important category of prominent phytochemicals affect different pathways of angiogenesis. Green tea polyphenols (epigallocatechin gallate) and soy bean isoflavones (genistein) are two examples involving an anti-angiogenic effect.

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