Cutaneous Expression of A Disintegrin-like and Metalloprotease domain containing Thrombospondin Type 1 motif-like 5 (ADAMTSL5) in Psoriasis goes beyond MelanocytesKathleen M Bonifacio, Norma Kunjravia, James G Krueger and Judilyn Fuentes-Duculan*
Laboratory for Investigative Dermatology, The Rockefeller University, New York, USA
- *Corresponding Author:
- Judilyn Fuentes-Duculan
Laboratory for Investigative Dermatology
The Rockefeller University 1230 York Avenue
Box 178, New York, USA
E-mail: [email protected]
Received Date: June 24, 2016; Accepted Date: September 10, 2016; Published Date: September 19, 2016
Citation: Bonifacio K M, Kunjravia N, Krueger J G, Fuentes-Duculan J (2016) Cutaneous Expression of a Disintegrin-like and Metalloprotease Domain containing Thrombospondin Type 1 Motif-like 5 (ADAMTSL5) in Psoriasis goes beyond Melanocytes. Pigmentary Disorders 3:244. doi: 10.4172/2376-0427.1000244
Copyright: © 2016 Bonifacio KM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A Disintegrin-like and Metalloprotease domain containing Thrombospondin type 1 motif-like 5 (ADAMTSL5) is a melanocyte-derived protein that has recently been implicated as an activating antigen for IL-17-producing T cells in psoriasis. There is a potential disconnect between the basal location of the melanocytes in the epidermis and the fact that T-cell infiltrates are seen mostly scattered in the epidermis with very large infiltrates in the dermis. Thus, we hypothesized that ADAMTSL5 may be expressed in other cells aside from melanocytes in skin. To further investigate the cutaneous expression of ADAMTSL5, we performed immunohistochemistry staining on lesional and nonlesional skin biopsies from psoriasis patients using three different commercially available antibodies. We confirmed that all ADAMTSL5 antibodies reacted with epidermal melanocytes. However, we also observed a strong expression of this protein in keratinocytes throughout the epidermis, and scattered expression in some dermal blood vessels and other perivascular dermal cells. Overall, the pattern of ADAMTSL5 expression is very similar to the infiltrating pattern of Tcells and dendritic cells in psoriasis lesions.