Cutaneous Manifestation of Systemic Lupus Erythematosus [SLE], Correlation with Specific Organ Involvement, Specific Auto Antibodies and Disease Activity and Outcome
- *Corresponding Author:
- Fathia Ehmouda Zaid
Faculty of Medicine
Benghazi University, Libya
E-mail: [email protected]
Received date: December 03, 2015; Accepted date: May 13, 2016; Published date: May 17, 2016
Citation: Zaid FE, Abudsalam N (2016) Cutaneous Manifestation of Systemic Lupus Erythematosus [SLE], Correlation with Specific Organ Involvement, Specific Auto Antibodies and Disease Activity and Outcome. Dermatol Case Rep 1: 108. doi:10.4172/dmcr.1000108
Copyright: © 2016 zaid FE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Cutaneous lesions are important as a diagnostic aid as these account for 4 out of 11 revised American Rheumatism Association criteria for disease classification Cutaneous manifestation of systemic lupus erythematosus (74.4%) and most patients had Butterfly rash (48.8%), Photosensitivity (41.9%), acute cutaneous lupus erythematosus (SCLE) (32.6%), Discoid lupus (20.9%), Nail lesions (16.3%), Alopecia (23.3%), oral nasal ulcer (37.2%), purpuric rash (23.3%), Raynaud phenomenon (16.3%), Livedo reticularis (9.3%), Telangiectasia’s (4.6%), and Urticarial lesion (2.3%). Lupus profundus (2.3%), Cutaneous manifestation of systemic lupus erythematosus are association with disease activity (97.7%), Cutaneous manifestation of systemic lupus erythematosus are association with musculoskeletal (MSK) (62.8%), Renal disease (27.9%), Hematologic disease (23.3%), Serositis (9.3%), Neurologic disease (14%),and cardiac disease (9.3%), Results: Cutaneous manifestation of systemic lupus erythematosus are association with positive ANA (90.3%) and negative ANA (9.3%), positive ds DNA (74.4%), positive Anti-Ro (69.8%), positive Anti-La (9.3%), positive Anti-SM (48.8%),and positive Anti-RNP (39.5%%). outcome of cutaneous manifestation of systemic lupus are skin atrophy and scarring (27.9%). pigmentation (25.6%) and alopecia (23.3%). Conclusion: The cutaneous lesions can provide valuable diagnosis of systemic lupus erythematosus. The most cutaneous manifestations are epidermal lesion then mucous-cutaneous lesion then vascular lesion, are associated with disease activity, and associated with high titer auto antibodies.