alexa Cyclosporine A Reduces Glial Scarring and Facilitates Functional Recovery Following Transient Focal Ischemia | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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Research Article

Cyclosporine A Reduces Glial Scarring and Facilitates Functional Recovery Following Transient Focal Ischemia

Hima CS Abeysinghe2, Laita Bokhari1,3, Gregory J Dusting4,5 and Carli L Roulston1*

1Neurotrauma Research team, Department of Medicine, St Vincent’s Campus, University of Melbourne, Victoria, Australia

2Department of Surgery, St Vincent’s Campus, University of Melbourne, Victoria, Australia

3Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia

4Cytoprotection Pharmacology Program, Centre for Eye Research, The Royal Eye and Ear Hospital Melbourne, Victoria, Australia.

5Department of Opthamology, Faculty of Medicine, University of Melbourne, Victoria, Australia

Corresponding Author:
Carli L Roulston
Team Leader Neurotrauma Research
Department of Medicine, St Vincent's Campus
University of Melbourne, Level 4,
Clinical Sciences Building 29 Regent Street
Fitzroy, Victoria, Australia 3065
Tel: 61 3 9288 3242
Fax: 61 3 9416 2581
E-mail: [email protected]

Received date: January 29, 2015; Accepted date: March 27, 2015; Published date: March 31, 2015

Citation: Abeysinghe HCS, Bokhari L, Dusting GJ, Roulston C (2015) Cyclosporine A Reduces Glial Scarring and Facilitates Functional Recovery Following Transient Focal Ischemia . J Neurol Neurophysiol 6:277. doi:10.4172/2155-9562.1000277

Copyright: © 2015 Abeysinghe HCS et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Technologic advances and superior survival with mechanical circulatory support (MCS) led to an expanding population that develops intra-abdominal conditions requiring intervention. Whether laparoscopy can be performed without detrimental effects on hemodynamics and device function is not well-described. Methods: Effects of laparoscopy performed on MCS were retrospectively assessed. Intraoperative hemodynamics and device function were compared to the same time interval 24h prior to surgery using intrapatient paired t-tests. Outcomes included survival, transfusion, thromboembolic events, and infection. Results: Twelve patients with ventricular assist devices or total artificial hearts underwent laparoscopy from 2012-2014. Median follow-up was 116 days. Operations included cholecystectomy, diagnostic laparoscopy, gastrojejunostomy, and gastrostomy. There were no differences between preoperative and intraoperative mean arterial pressure, heart rate, or inotrope or vasopressor requirements (p>0.05). Device fill volume, flow, rate, and power were unchanged (p>0.05), while pulsatility index decreased by 0.2, 95% CI [.03, 0.36], with laparoscopy (p=0.03). All intraoperative fluctuations in hemodynamics and device function improved with reduction of pneumoperitoneum, adjusting device speed, or pharmacologic support. There were no operative mortalities. 30-day survival and survival to discharge were 75% and 50%. Despite antiplatelet therapy and preoperative INR of 2.2±0.9, there were no re-operations for bleeding and 50% did not require transfusion. Two patients with recent cardiac surgery had thromboembolic events: 1 stroke, 1 device thrombus. None had postoperative bacteremia or drive-line infection. Conclusions: Laparoscopy can be performed on mechanical circulatory support with low morbidity and mortality and minimal perturbations in hemodynamics and device function.

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