alexa Cyromazine and Chlorpyrifos Induced Renal Toxicity in Rats: The Ameliorated Effects of Green Tea Extract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
Open Access

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Research Article

Cyromazine and Chlorpyrifos Induced Renal Toxicity in Rats: The Ameliorated Effects of Green Tea Extract

Tarek M. Heikal1, Abdel-Tawab H. Mossa1*, Gehan I. Kh. Marei2, Mona A. Abdel Rasoul2
1Environmental Toxicology Research Unit (ETRU), Pesticide Chemistry Department, National Research Centre (NRC), Cairo, Egypt
2Department of Pest Control and Environmental Protection, Faculty of Agriculture, Damanhour University, Damanhour, Egypt
Corresponding Author : Abdel-Tawab H. Mossa
Environmental Toxicology Research Unit (ETRU)
Pesticide Chemistry Department
National Research Centre (NRC),Cairo, Egypt
Tel: (202)-33371211/33371615
Fax: (202)-33370931
Mobile: 202 01005038504
E-mail: [email protected]
Received May 19, 2012; Accepted June 07, 2012; Published June 09, 2012
Citation: Heikal TM, Mossa ATH, Marei GIK, Abdel Rasoul MA (2012) Cyromazine and Chlorpyrifos Induced Renal Toxicity in Rats: The Ameliorating Effects of Green Tea Extract. J Environ Anal Toxicol 2:146. doi: 10.4172/2161-0525.1000146
Copyright: © 2012 Heikal TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In the present study, the protective effect of an aqueous extract of green tea (GT) against renal oxidative damage and nephrotoxicity induced by cyromazine (Cyr), chlorpyrifos (CPF) and their combination in male rats was undertaken. Eight groups containing six rats each were selected. Group I served as control. Groups II, III and IV rats were given a single daily oral doses of Cyr (169.35 mg kg-1, 1/20 LD50, in corn oil), CPF (6.75 mg kg-1 kg-1,1/20 LD50, in corn oil) and their combination for 28 consecutive days, respectively. Group V permitted free access to solubilised GT (1.5%w/v in water) as the sole drinking fluid. Groups VI, VII and VIII rats were given the same doses as groups II, III and IV and simultaneously permitted free access to solubilised GT as the sole drinking fluid. Significant reduction in body weight and elevation in kidney weight were observed in insecticides exposed rats compared to control. Significant perturbations of renal function as evidenced via increase in blood urea nitrogen (BUN) and serum creatinine level were observed in treated rats. Also, renal oxidative damage was observed in insecticide-treated rats as evidenced via augmentation in kidney lipid peroxidation (LPO) as well as depletion in kidney antioxidant enzymes; catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Histopathological analysis of the kidney revealed that supplementation with GT resulted in nil to mild in vacuolization, swelling and degeneration in the endothelium of glomerular tuft and the epithelium of lining tubules. In conclusion, the use of green tea extract appeared to be beneficial to rats, to a great extent by attenuating and restoring the damage sustained by insecticide exposure.

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