alexa Cystatin C - A Biomarker for Early Nephropathy in Type 2 Diabetic Patients

Journal of Molecular Biomarkers & Diagnosis
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Review Article

Cystatin C - A Biomarker for Early Nephropathy in Type 2 Diabetic Patients

Temesgen Fiseha*

Department of Clinical Laboratory Science, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia

*Corresponding Author:
Temesgen Fiseha
Department of Clinical Laboratory Science
College of Medicine and Health Science
Wollo University, Dessie, Ethiopia
Tel: 033-3115211
E-mail: [email protected]

Received date: November 30, 2015; Accepted date:December 23, 2015; Published date: December 26, 2015

Citation: Fiseha T (2015) Cystatin C - A Biomarker for Early Nephropathy in Type 2 Diabetic Patients. J Mol Biomarkers Diagn S8:009. doi:10.4172/2155-9929.S8-009

Copyright: © 2015 Fiseha T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Diabetic nephropathy (DN) is a serious complication of diabetes associated with an increased risk of mortality, and cardiovascular and renal outcomes. Cystatin C, a 13 kD non-glycosylated basic protein, may be elevated in diabetic patients even before the appearance of microalbuminuria, and can be used as useful marker for detecting nephropathy in patients with normoalbuminuria (early nephropathy). We reviewed the recent literatures to determine if serum or urine cystatin C measurements could be useful as a marker to detect early DN in type 2 diabetic patients. Our search identified a total of 23 studies that have been published to date. Cystatin C measurement was carried out using immunoturbidimetric assays, Dade Behring Cystatin C assay, particle enhanced nephlometric immnuno assays, ELISA kits, or latex agglutination tests. Serum or urinary levels of cystatin C were elevated in type 2 diabetic patients compared to non-diabetic controls, including in patients who had no signs indicating nephropathy (without microalbuminuria). A significant positive correlation was found between cystatin C levels and albuminuria, suggesting its ability as a marker reflecting the degree of renal impairment in type 2 DN. Despite the promise of cystatin C as a biomarker, further large, multicenter prospective studies are still needed to confirm its clinical utility as a screening tool for early type 2 DN in every day practice.


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