alexa Cytochrome 2C19 Enzyme Polymorphism Frequency in Different Indigenous Ethnic Groups in Russian Federation: A Systematic Review | OMICS International | Abstract
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Cytochrome 2C19 Enzyme Polymorphism Frequency in Different Indigenous Ethnic Groups in Russian Federation: A Systematic Review

Karin Mirzaev1*, Dmitriy Sychev2, Goar Arutyunyan1, Alla Yugay1 and Denis Andreev3

1I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

2Department of Clinical Pharmacology, Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation

3Department of Preventative Cardiology and Acute Cardiac Care, I.M.Sechenov First Mocsow State Medical University, Moscow, Russian Federation

*Corresponding Author:
Karin Mirzaev
I.M. Sechenov First Moscow State Medical University
Moscow, Russian Federation, Trubetskaya 8 street
119991 Moscow, Russian Federation
Tel: +79852720253
Fax: +74959155801
E-mail: [email protected]

Received date: April 24, 2014; Accepted date: June 27, 2014; Published date: July 04, 2014

Citation: Mirzaev K, Sychev D, Arutyunyan G, Yugay A, Andreev D (2014) Cytochrome 2C19 Enzyme Polymorphism Frequency in Different Indigenous Ethnic Groups in Russian Federation: A Systematic Review J Pharmacogenomics Pharmacoproteomics 5:136. doi: 10.4172/2153-0645.1000136

Copyright: © 2014 Mirzaev K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background and objective: Genetically determined diversity in the activity of cytochrome P450 (CYP) – enzyme regulating the biotransformation of drugs and xenobiotics – is one of the main causes of interindividual differences in response to pharmacotherapy. The objective of this review is to analyze the prevalence of polymorphic markers of gene CYP2C19, associated with the violation of the pharmacological response to clopidogrel among the various ethnic groups living in the Russian Federation.

Methods: A literature review was conducted using the following databases: MEDLINE and eLIBRARY.RU. Russian language articles published between 20032003 (the first publication in Russians) and 2014 were reviewed.

Results: The authors detected 11 original research studies on CYP2C19 gene in 11 indigenous ethnic groups of Russian Federation. According to the research data, the frequency of CYP2C19*2 and CYP2C19*3 markers prevalence is higher in the Mongolian race (with maximum CYP2C19*2 frequency in the Kalmyks - 25, 0 % and CYP2C19*3 in Tatars – 21,0 %). CYP2C19*17 allele has been studied only in Russians, and was about the same as in the Caucasian race (14,0 %).

Conclusion: The results of the investigation will be beneficial for developing guidelines for CYPC19 genotype– directed antiplatelet therapy for each region of Russia.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037


James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals


Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T


[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7