alexa Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes | OMICS International | Abstract
ISSN:2157-7463

Journal of Petroleum & Environmental Biotechnology
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Research Article

Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes

Santosh Kumar*, Mengyao Jin and James L Weemhoff
School of Pharmacy, University of Missouri, USA
Corresponding Author : Santosh Kumar
Pharmacology and Toxicology
School of Pharmacy
University of Missouri-Kansas City
2464 Charlotte, St. Kansas City, MO 64108, USA
Tel: 816-235-5494
Fax: 816-235-1776
E-mail: [email protected]
Received May 27, 2012; Accepted July 25, 2012; Published July 28, 2012
Citation: Santosh Kumar, Jin M, Weemhoff JL (2012) Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes. J Pet Environ Biotechnol 3:127. doi:10.4172/2157-7463.1000127
Copyright: © 2012 Santosh Kumar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

There is an increasing demand for versatile and ubiquitous Cytochrome P450 (CYP) biocatalysts for biotechnology, medicine, and bioremediation. In the last decade there has been an increase in realization of the power of CYP biocatalysts for detoxification of soil and water contaminants using transgenic plants. However, the major limitations of mammalian CYP enzymes are that they require CYP reductase (CPR) for their activity, and they show relatively low activity, stability, and expression. On the other hand, bacterial CYP enzymes show limited substrate diversity and usually do not metabolize herbicides and industrial contaminants. Therefore, there has been a considerable interest for biotechnological industries and the scientific community to design CYP enzymes to improve their catalytic efficiency, stability, expression, substrate diversity, and the suitability of P450-CPR fusion enzymes. Engineered CYP enzymes have potential for transgenic plants-mediated phytoremediation of herbicides and environmental contaminants. In this review we discuss: 1) the role of CYP enzymes in phytoremediation using transgenic plants, 2) problems associated with wild-type CYP enzymes in phytoremediation, and 3) examples of engineered CYP enzymes and their potential role in transgenic plant-mediated phytoremediation.

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