alexa Cytokine/Chemokine Expression in Reflex Tears from Employers Exposed to Computer Screens in a Healthy Office Environment | OMICS International | Abstract
ISSN: 2165-8048

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Research Article

Cytokine/Chemokine Expression in Reflex Tears from Employers Exposed to Computer Screens in a Healthy Office Environment

Carmen Galbis-Estrada1, Maria D Pinazo-Durán1*, Esther Escrivá-Pastor1, Maria A Parras2 and Alfredo Ribelles2
1Faculty of Medicine, University of Valencia, Spain
2Occupational Medical Services of the General Treasury of Social Security, Valencia, Spain
*Corresponding Author : Maria D Pinazo-Duran
Faculty of Medicine
University of Valencia, Spain
Tel: 34963864269
Fax: 34963864269
E-mail: [email protected]
Received May 12, 2013; Accepted June 14, 2013; Published June 25, 2013
Citation: Galbis-Estrada C, Pinazo-Durán MD, Escrivá-Pastor E, Parras MA, RIbelles A (2013) Cytokine/Chemokine Expression in Reflex Tears from Employers Exposed to Computer Screens in a Healthy Office Environment. Intern Med 3:124. doi: 10.4172/2165-8048.1000124
Copyright: © 2013 Estrada CG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To inform employees exposed to computer screens (CSs) about the risk of dry eye disorders (DEDs) and how to prevent them.
Methods: From a total of 800 public-sector employees, eighty-eight CSs users were randomly selected to participate in an interview and an ophthalmic examination, and compared to thirty-six healthy volunteers no CSs users including family members, nurses and assistants. Environmental conditions in the workplace were documented. Reflex tear samples were collected simultaneously from both eyes and were later subjected to a multiplexed particlebased
flow cytometry assay. A specific set of immune response biomarkers was analyzed.
Results: The mean age was 52.17 (5.17) years; 27% were men and 73% women. DEDs were newly diagnosed in 86% of the participants. Mean CS exposure was 4.8 (1.27) hours. Environmental workplace conditions complied with general standards. Schirmer test results and blinking frequency were pathologic in up to 2/3 of the employers exposed to CSs. Immune response biomarkers were detected in 90% of tear samples. Compared with records of healthy, non-exposed control subjects in a pre-existing database, tear samples of the participants exposed to CSs had significantly higher levels of interleukins (IL) (IL1B, IL2, IL6, IL8), GM-CSF, IFG, and VEGF.
Conclusion: Employee exposure to CSs was a major risk factor for DED, being inflammation a main contributor to ocular surface pathogenesis.

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