Cytological Result of In Situ Ductal Carcinoma in Nipple Discharge: A Rare DiagnosisJosé Cândido Caldeira Xavier-Júnior1*, Rafael Bispo Paschoalini1, Rafael André Gonçalves Rosa2, Vinicius Capistrano Ferreira3, Mariangela Esther Alencar Marques1, José Ricardo Paciência Rodrigues2, Sonia Marta Moriguichi3 and Rozany Mucha Dufloth1
- *Corresponding Author:
- José Cândido Caldeira Xavier Júnior
Resident of Pathology, Department of Pathology, Botucatu Medical School
Paulista State University (UNESP), Rubião Júnior s/n, 18618-970. Botucatu – SP, Brazil
Tel: + 55 (14) 3811-6238
Fax: + 55 (14) 38152348
E-mail: [email protected]
Received Date: July 25, 2014; Accepted Date: October 16, 2014; Published Date: October 18, 2014
Citation: Xavier-Júnior JCC, Paschoalini RB, Rosa RAG, Ferreira VC, Marques MEA, et al. (2014) Cytological Result of In Situ Ductal Carcinoma in Nipple Discharge: A Rare Diagnosis . J Cytol Histol 5:284.doi: 10.4172/2157-7099.1000284
Copyright: 2014 Xavier-Júnior JCC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: More than half of women present nipple discharge during reproductive age.
Case: This case is about a 36 years old woman with unilateral spontaneous hyaline nipple discharge associated with breast pain. The study of scintimammography was compatible with multifocal proliferative lesion in situ. It was performed cytological smear of nipple discharge. It was paucicellular smear represented by cluster of ductal cells in three-dimensional design with hyperchromatic nuclei in the presence of myoepithelial cells. Red cells and signs of necrosis were not observed. The diagnosis of in situ ductal carcinoma was confirmed in biopsy and mastectomy specimen through the expression of calponin in myoepithelial cells at immunohistochemistry. It is known that the cytological examination of nipple discharge has low sensitivity and specificity. However, it is an easy and inexpensive procedure. Suspicious or positive results, may be important for guidance workup of patients in order to perform earlier diagnosis of malignancy.
Conclusion: this case demonstrates that in situ ductal carcinoma can be characterized by positive nipple discharge, and cytology sample is an important tool for the diagnosis of suspicion of malignancy and further diagnostic investigation.