alexa Cytomegalovirus (CMV)-Reactivation Influences T-Cell Differentiation and CMV-Specific T-Cell Reconstitution after Stem Cell Transplantation | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Cytomegalovirus (CMV)-Reactivation Influences T-Cell Differentiation and CMV-Specific T-Cell Reconstitution after Stem Cell Transplantation

Jolanda Scherrenburg1, Floor Pietersma1, Ronald Jacobi1, Rob Schuurman2, Ellen Meijer3 and Debbie van Baarle1,4*
1Department of Immunology, University Medical Center Utrecht, Utrecht, Netherlands
2Department of Virology, University Medical Center Utrecht, Utrecht, Netherlands
3Department of Hematology, Erasmus Medical Center, Rotterdam, Netherlands
4Department of Internal Medicine and Infectious Diseases, UMCU, Netherlands
Corresponding Author : Dr. Debbie van Baarle
Department of Immunology, University Medical Center Utrecht
Lundlaan 6, 3584 EA Utrecht, Netherlands
Tel: +31-88-7553946/4306
Fax: +31-88-7554305
E-mail: [email protected]
Received June 27, 2012; Accepted July 24, 2012; Published July 31, 2012
Citation: Scherrenburg J, Pietersma F, Jacobi R, Schuurman R, Meijer E, et al. (2012) Cytomegalovirus (CMV)-Reactivation Influences T-Cell Differentiation and CMV-Specific T-Cell Reconstitution after Stem Cell Transplantation. J Clin Cell Immunol S9:001. doi:10.4172/2155-9899.S9-001
Copyright: © 2012 Scherrenburg J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

CMV-specific T cells were shown to be important for protection against CMV-disease in SCT recipients. Here we investigated specific T-cell features like effector cell differentiation and perforin-expression as well as CMV-specific T cells after SCT in relation to CMV-reactivation. To this end, CD4+ and CD8+ T-cell characteristics (differentiation, activation and functional CMV-specific immunity) of SCT patients with (n=13) or without (n=8) CMV-reactivation were analysed longitudinally by flow cytometry. CMV-specific IFNγ-production as measured by intracellular staining and proliferation as measured by CFSE dye dilution were analysed after stimulation with overlapping peptide pools of the tegument protein pp65 and immediate early antigen 1. A more differentiated phenotype, up-regulation of the activation markers CD38 and HLA-DR on CD4+ T cells and increased expression of perforin on CD8+ T cells was more frequently observed in patients with CMV-reactivation compared to patients without reactivation. Interestingly, these T-cell features were often already different early after SCT. In addition, CMV-specific CD8+ T-cell responses, both based on IFNγ-production as well as proliferation, directed against both pp65 and IE1 tended to be present more frequently in patients with CMV-reactivation compared to patients without reactivation. These data suggest that CMV-reactivation influences CMV-specific T-cell reconstitution after SCT and that early T-cell differentiation differences may be helpful in predicting viral reactivations.

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